Research Article

A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity

Table 2

Synthesis and anticancer activity of 2-aryl benzimidazoles against MCF7 and HL60 cell lines.

Entry R R1 Reaction time (min) YieldaIC50 ( M)b
MCF7HL60

5aH453682.tab.002a209435.6730.73
5bH453682.tab.002b309027.6328.68
5cH453682.tab.002c189521.8124.74
5dH453682.tab.002d208427.1126.71
5eH453682.tab.002e128927.0025.28
5fH453682.tab.002f169026.2525.03
5gH453682.tab.002g159524.4126.33
5hH453682.tab.002h197829.6726.52
5iH453682.tab.002i208230.4229.55
6aCOOH453682.tab.002j129122.2024.88
6bCOOH453682.tab.002k307023.2825.09
6cCOOH453682.tab.002l189024.5125.78
6dCOOH453682.tab.002m177825.3030.32
6eCOOH453682.tab.002n158817.6522.10
7aPhCO453682.tab.002o179117.3219.64
7bPhCO453682.tab.002p228917.3219.88
7cPhCO453682.tab.002q129417.4518.13
8Bisbenzimidazole358017.4430.69

Cisplatin40.4541.08

1,2-phenylenediamine 1 mmol, m-nitrobenzaldehyde 1 mmol catalyst (0.20 mmol supported on silica) in ACN. Isolated yields after purification.
bIC50 50% inhibition concentration in M.