Modulation of Vitamin D Status and Dietary Calcium Affects Bone Mineral Density and Mineral Metabolism in Göttingen Minipigs

Table 2

Baseline values and time course of body weights and markers of calcium metabolism and bone turnover in calcium and vitamin D deficiency osteomalacia.

	Control (𝑛=9)						CaD(−) (𝑛=10)
	𝑡0		𝑡8		𝑡15		𝑡0		𝑡8		𝑡15
	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM
Body weight (kg)	33.1	1.6	33.5	1.3	33.1	1.3	32.4	1.8	32.0	1.2	31.2	1.5
Plasma
Ca (mg/L)	110.1	3.3	107.6	2.4	107.6	2.2	111.0	1.9	108.5	1.6	101.5	1.5^a,x
P (mg/L)	49.7	1.9	46.7	2.7	52.7	2.1	49.5	2.4	47.7	0.8	50.1	1.3
AP (U/L)	116.9	28.9	153.5	59.6	185.0	75.2	139.1	23.4	200.7	44.1^x	169.2	22.3
BAP (U/L)	29.6	4.6	29.6	4.2	23.3	3.2	38.0	4.9	36.1	4.6	36.0	5.8^[a]
OPG (pmol/L)	0.9	0.1	0.6	0.1	nd		0.8	0.1	0.73	0.04^[x]	nd
Urine
DPD (nmol/24 h)	139.9	25.5	116.0	12.2	84.3	12.2	120.3	2.3	128.3	16.9	81.8	7.6
DPD/Crea (nmol/mmol)	10.1	3.2	6.2	0.7	6.7	1.6	11.8	2.9	5.5	0.9^[x]	5.5	0.9

Mean values and standard error of the mean. AP: total alkaline phosphatase; BAP: bone alkaline phosphatase, OPG: osteoprotegerin; nd: not determined; DPD: deoxypyridinoline; Crea: creatinine. Samples are 8–10. Significantly different from the value of the control group at the same time point with ^[a]𝑃≤0.1; ^a𝑃≤0.05. Significantly different from the baseline value with ^[x]𝑃≤0.1; ^x𝑃≤0.05.