Table of Contents
ISRN Orthopedics
Volume 2013 (2013), Article ID 471695, 12 pages
http://dx.doi.org/10.1155/2013/471695
Review Article

Vitamin D Status and Spine Surgery Outcomes

Nola Physical Therapy, 2 West 45th Street, Suite 208, New York, NY 10036, USA

Received 20 February 2013; Accepted 19 March 2013

Academic Editors: M. Kawakami, C.-H. Lee, and B. K. Weiner

Copyright © 2013 William J. Rodriguez and Jason Gromelski. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Karlson, H. B. F. Dixon, B. L. Horecker et al., “International Union of Pure and Applied Chemistry and International Union of Biochemistry—nomenclature of vitamin D,” Pure and Applied Chemistry, vol. 54, no. 8, pp. 1511–1516, 1982. View at Google Scholar
  2. J. G. Haddad, L. Y. Matsuoka, B. W. Hollis, Y. Z. Hu, and J. Wortsman, “Human plasma transport of vitamin D after its endogenous synthesis,” Journal of Clinical Investigation, vol. 91, no. 6, pp. 2552–2555, 1993. View at Google Scholar · View at Scopus
  3. G. Ponchon and H. F. DeLuca, “The role of the liver in the metabolism of vitamin D,” Journal of Clinical Investigation, vol. 48, no. 7, pp. 1273–1279, 1969. View at Google Scholar · View at Scopus
  4. A. W. Norman, “Evidence for a new kidney-produced hormone, 1,25-dihydroxycholecalciferol, the proposed biologically active form of vitamin D,” American Journal of Clinical Nutrition, vol. 24, no. 11, pp. 1346–1351, 1971. View at Google Scholar · View at Scopus
  5. R. Bouillon, W. H. Okamura, and A. W. Norman, “Structure-function relationships in the vitamin D endocrine system,” Endocrine Reviews, vol. 16, no. 2, pp. 200–256, 1995. View at Google Scholar · View at Scopus
  6. M. F. Holick, N. C. Binkley, H. A. Bischoff-Ferrari et al., “Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline,” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 7, pp. 1911–1930, 2011. View at Publisher · View at Google Scholar
  7. A. Unnanuntana, B. J. Rebolledo, B. P. Gladnick et al., “Does vitamin D status affect the attainment of in-hospital functional milestones after total hip arthroplasty?” Journal of Arthroplasty, vol. 27, no. 3, pp. 482–489, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Unnanuntana, A. Saleh, J. T. Nguyen et al., “Low vitamin D status does not adversely affect short-term functional outcome after total hip arthroplasty,” Journal of Arthroplasty, vol. 28, no. 2, pp. 315–322, 2013. View at Publisher · View at Google Scholar
  9. L. Bogunovic, A. D. Kim, B. S. Beamer, J. Nguyen, and J. M. Lane, “Hypovitaminosis D in patients scheduled to undergo orthopaedic surgery: a single-center analysis,” Journal of Bone and Joint Surgery. American, vol. 92, no. 13, pp. 2300–2304, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Lotfi, A. M. Abdel-Nasser, A. Hamdy, A. A. Omran, and M. A. El-Rehany, “Hypovitaminosis D in female patients with chronic low back pain,” Clinical Rheumatology, vol. 26, no. 11, pp. 1895–1901, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. G. E. Stoker, J. M. Buchowski, K. H. Bridwell, K. D. Riew, and L. P. Zebala, “Vitamin D status of adults undergoing surgical spinal fusion,” in Proceedings of the 26th Annual Meeting of the North American Spine Society, Chicago, Ill, USA, November 2011.
  12. H. A. Bischoff-Ferrari, Y. Zhang, D. P. Kiel, and D. T. Felson, “Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis,” Arthritis and Rheumatism, vol. 53, no. 6, pp. 821–826, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. C. M. Gordon, K. C. DePeter, H. A. Feldman, E. Grace, and S. J. Emans, “Prevalence of vitamin D deficiency among healthy adolescents,” Archives of Pediatrics and Adolescent Medicine, vol. 158, no. 6, pp. 531–537, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. G. A. Plotnikoff and J. M. Quigley, “Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain,” Mayo Clinic Proceedings, vol. 78, no. 12, pp. 1463–1470, 2003. View at Google Scholar · View at Scopus
  15. H. A. Bischoff-Ferrari, E. Giovannucci, W. C. Willett, T. Dietrich, and B. Dawson-Hughes, “Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes,” American Journal of Clinical Nutrition, vol. 84, no. 1, pp. 18–28, 2006. View at Google Scholar · View at Scopus
  16. M. K. Thomas, D. M. Lloyd-Jones, R. I. Thadhani et al., “Hypovitaminosis D in medical inpatients,” The New England Journal of Medicine, vol. 338, no. 12, pp. 777–783, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Binkley, R. Novotny, D. Krueger et al., “Low vitamin D status despite abundant sun exposure,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2130–2135, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. IOM, Institutue of Medicine Dietary Reference Intakes for Calcium and Vitamin D, National Academies Press, Washington, DC, USA, 2010.
  19. D. A. Hanley, A. Cranney, G. Jones et al., “Vitamin D in adult health and disease: a review and guideline statement from osteoporosis Canada,” CMAJ, vol. 182, no. 12, pp. E610–E618, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Dawson-Hughes, R. P. Heaney, M. F. Holick, P. Lips, P. J. Meunier, and R. Vieth, “Estimates of optimal vitamin D status,” Osteoporosis International, vol. 16, no. 7, pp. 713–716, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Dawson-Hughes, A. Mithal, J. P. Bonjour et al., “IOF position statement: vitamin D recommendations for older adults,” Osteoporosis International, vol. 21, no. 7, pp. 1151–1154, 2010. View at Google Scholar · View at Scopus
  22. R. Vieth, “Why the minimum desirable serum 25-hydroxyvitamin D level should be 75 nmol/L (30 ng/ml),” Best Practice & Research Clinical Endocrinology & Metabolism, vol. 25, no. 4, pp. 681–691, 2011. View at Publisher · View at Google Scholar
  23. S. S. Harris, B. Dawson-Hughes, and G. A. Perrone, “Plasma 25-hydroxyvitamin D responses of younger and older men to three weeks of supplementation with 1800 IU/day of vitamin D,” Journal of the American College of Nutrition, vol. 18, no. 5, pp. 470–474, 1999. View at Google Scholar · View at Scopus
  24. R. Vieth, “Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety,” American Journal of Clinical Nutrition, vol. 69, no. 5, pp. 842–856, 1999. View at Google Scholar · View at Scopus
  25. R. P. Heaney, K. M. Davies, T. C. Chen, M. F. Holick, and M. J. Barger-Lux, “Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol,” American Journal of Clinical Nutrition, vol. 77, no. 1, pp. 204–210, 2003. View at Google Scholar · View at Scopus
  26. R. Vieth, D. E. Cole, G. A. Hawker, H. M. Trang, and L. A. Rubin, “Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it,” European Journal of Clinical Nutrition, vol. 55, no. 12, pp. 1091–1097, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Glerup, K. Mikkelsen, L. Poulsen et al., “Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited,” Journal of Internal Medicine, vol. 247, no. 2, pp. 260–268, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. R. P. Heaney, M. S. Dowell, C. A. Hale, and A. Bendich, “Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D,” Journal of the American College of Nutrition, vol. 22, no. 2, pp. 142–146, 2003. View at Google Scholar · View at Scopus
  29. R. Vieth, “Why the optimal requirement for vitamin D3 is probably much higher than what is officially recommended for adults,” Journal of Steroid Biochemistry and Molecular Biology, vol. 89-90, no. 1–5, pp. 575–579, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. B. W. Hollis, “Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D,” Journal of Nutrition, vol. 135, no. 2, pp. 317–322, 2005. View at Google Scholar · View at Scopus
  31. V. Tangpricha, E. N. Pearce, T. C. Chen, and M. F. Holick, “Vitamin D insufficiency among free-living healthy young adults,” American Journal of Medicine, vol. 112, no. 8, pp. 659–662, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. M. J. Barger-Lux, R. P. Heaney, S. Dowell, T. C. Chen, and M. F. Holick, “Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men,” Osteoporosis International, vol. 8, no. 3, pp. 222–230, 1998. View at Publisher · View at Google Scholar · View at Scopus
  33. R. P. Heaney, “The vitamin D requirement in health and disease,” Journal of Steroid Biochemistry and Molecular Biology, vol. 97, no. 1-2, pp. 13–19, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Datta, M. Alfaham, D. P. Davies et al., “Vitamin D deficiency in pregnant women from a non-European ethnic minority population—an interventional study,” BJOG, vol. 109, no. 8, pp. 905–908, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Lehtonen-Veromaa, T. Möttönen, I. Nuotio, K. Irjala, and J. Viikari, “The effect of conventional vitamin D2 supplementation on serum 25(OH)D concentration is weak among peripubertal Finnish girls: a 3-y prospective study,” European Journal of Clinical Nutrition, vol. 56, no. 5, pp. 431–437, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. E. A. Yetley, “Assessing the vitamin D status of the US population,” American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 558S–564S, 2008. View at Google Scholar · View at Scopus
  37. S. A. Abrams, I. J. Griffin, K. M. Hawthorne, S. K. Gunn, C. M. Gundberg, and T. O. Carpenter, “Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 10, pp. 5576–5581, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. N. Binkley, R. Novotny, D. Krueger et al., “Low vitamin D status despite abundant sun exposure,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2130–2135, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Parry, E. Sullivan, and A. C. Scott, “Vitamin D sufficiency screening in preoperative pediatric orthopaedic patients,” Journal of Pediatric Orthopaedics, vol. 31, no. 3, pp. 331–333, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. M. S. LeBoff, W. G. Hawkes, J. Glowacki, J. Yu-Yahiro, S. Hurwitz, and J. Magaziner, “Vitamin D-deficiency and post-fracture changes in lower extremity function and falls in women with hip fractures,” Osteoporosis International, vol. 19, no. 9, pp. 1283–1290, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. M. R. Brinker, D. P. O'Connor, Y. T. Monla, and T. P. Earthman, “Metabolic and endocrine abnormalities in patients with nonunions,” Journal of Orthopaedic Trauma, vol. 21, no. 8, pp. 557–570, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. W. E. Plehwe and R. P. L. Carey, “Spinal surgery and severe vitamin D deficiency,” Medical Journal of Australia, vol. 176, no. 9, pp. 438–439, 2002. View at Google Scholar · View at Scopus
  43. S. G. Pneumaticos, C. P. Zafeiris, E. Chronopoulos, E. Kassi, and G. P. Lyritis, “Vitamin D deficiency resulting to a subsequent vertebral fracture after kyphoplasty,” Journal of Musculoskeletal Neuronal Interactions, vol. 11, no. 1, pp. 81–83, 2011. View at Google Scholar · View at Scopus
  44. G. Schwalfenberg, “Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series,” Journal of the American Board of Family Medicine, vol. 22, no. 1, pp. 69–74, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. S. Waikakul, “Serum 25-hydroxy-calciferol level and failed back surgery syndrome,” The Journal of Orthopaedic Surgery, vol. 20, no. 1, pp. 18–22, 2012. View at Google Scholar
  46. T. H. Kim, J. Y. Yoon, B. H. Lee et al., “Changes in vitamin D status after surgery in female patients with lumbar spinal stenosis and its clinical significance,” Spine, vol. 37, no. 21, pp. E1326–E1330, 2012. View at Google Scholar
  47. G. E. Stoker, J. M. Buchowski, K. H. Bridwell, L. G. Lenke, K. D. Riew, and L. P. Zebala, “Preoperative vitamin D status of adults undergoing surgical spinal fusion,” Spine, vol. 38, no. 6, pp. 507–515, 2013. View at Publisher · View at Google Scholar
  48. S. Al Faraj and K. Al Mutairi, “Vitamin D deficiency and chronic low back pain in Saudi Arabia,” Spine, vol. 28, no. 2, pp. 177–179, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. K. V. Knutsen, M. Brekke, S. Gjelstad, and P. Lagerløv, “Vitamin D status in patients with musculoskeletal pain, fatigue and headache: a cross-sectional descriptive study in a multi-ethnic general practice in Norway,” Scandinavian Journal of Primary Health Care, vol. 28, no. 3, pp. 166–171, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. J. MacLaughlin and M. F. Holick, “Aging decreases the capacity of human skin to produce vitamin D3,” Journal of Clinical Investigation, vol. 76, no. 4, pp. 1536–1538, 1985. View at Google Scholar · View at Scopus
  51. A. S. Growdon, C. A. Camargo Jr., S. Clark, M. Hannon, and J. M. Mansbach, “Serum 25-hydroxyvitamin D levels among Boston trainee doctors in winter,” Nutrients, vol. 4, no. 3, pp. 197–207, 2012. View at Publisher · View at Google Scholar
  52. T. L. Clemens, J. S. Adams, S. L. Henderson, and M. F. Holick, “Increased skin pigment reduces the capacity of skin to synthesise vitamin D3,” Lancet, vol. 1, no. 8263, pp. 74–76, 1982. View at Google Scholar · View at Scopus
  53. A. R. Webb, L. Kline, and M. F. Holick, “Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin,” Journal of Clinical Endocrinology and Metabolism, vol. 67, no. 2, pp. 373–378, 1988. View at Google Scholar · View at Scopus
  54. L. Y. Matsuoka, L. Ide, J. Wortsman, J. A. MacLaughlin, and M. F. Holick, “Sunscreens suppress cutaneous vitamin D3 synthesis,” Journal of Clinical Endocrinology and Metabolism, vol. 64, no. 6, pp. 1165–1168, 1987. View at Google Scholar · View at Scopus
  55. L. Y. Matsuoka, J. Wortsman, M. J. Dannenberg, B. W. Hollis, Z. Lu, and M. F. Holick, “Clothing prevents ultraviolet-B radiation-dependent photosynthesis of vitamin D3,” Journal of Clinical Endocrinology and Metabolism, vol. 75, no. 4, pp. 1099–1103, 1992. View at Publisher · View at Google Scholar · View at Scopus
  56. G. El-Hajj Fuleihan, M. Nabulsi, M. Choucair et al., “Hypovitaminosis D in healthy schoolchildren,” Pediatrics, vol. 107, no. 4, p. E53, 2001. View at Google Scholar · View at Scopus
  57. S. Saintonge, H. Bang, and L. M. Gerber, “Implications of a new definition of vitamin D deficiency in a multiracial US adolescent population: the National Health and Nutrition Examination Survey III,” Pediatrics, vol. 123, no. 3, pp. 797–803, 2009. View at Publisher · View at Google Scholar · View at Scopus
  58. G. Guardia, N. Parikh, T. Eskridge, E. Phillips, G. Divine, and D. S. Rao, “Prevalence of vitamin D depletion among subjects seeking advice on osteoporosis: a five-year cross-sectional study with public health implications,” Osteoporosis International, vol. 19, no. 1, pp. 13–19, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. S. Arunabh, S. Pollack, J. Yeh, and J. F. Aloia, “Body fat content and 25-hydroxyvitamin D levels in healthy women,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 1, pp. 157–161, 2003. View at Publisher · View at Google Scholar · View at Scopus
  60. G. E. Stoker, J. M. Buchowski, and M. E. Stoker, “Prior cholecystectomy as a predictor of preoperative vitamin D deficiency in adults undergoing spine surgery,” Archives of Surgery, vol. 147, no. 6, pp. 577–578, 2012. View at Publisher · View at Google Scholar
  61. E. Kamycheva, R. M. Joakimsen, and R. Jorde, “Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway,” Journal of Nutrition, vol. 133, no. 1, pp. 102–106, 2003. View at Google Scholar · View at Scopus
  62. U. Grober and K. Kisters, “Influence of drugs on vitamin D and calcium metabolism,” Dermato-Endocrinology, vol. 4, no. 2, pp. 158–166, 2012. View at Publisher · View at Google Scholar
  63. M. F. Holick, “Vitamin D deficiency: what a pain it is,” Mayo Clinic Proceedings, vol. 78, no. 12, pp. 1457–1459, 2003. View at Google Scholar · View at Scopus
  64. S. S. Hannah and A. W. Norman, “1α,25(OH)2 vitamin D3-regulated expression of the eukaryotic genome,” Nutrition Reviews, vol. 52, no. 11, pp. 376–382, 1994. View at Google Scholar · View at Scopus
  65. R. S. Khoury, J. Weber, and M. C. Farach-Carson, “Vitamin D metabolites modulate osteoblast activity by Ca+2 influx- independent genomic and Ca+2 influx-dependent nongenomic pathways,” Journal of Nutrition, vol. 125, no. 6, supplement, pp. 1699S–1703S, 1995. View at Google Scholar · View at Scopus
  66. L. N. Drittanti, R. L. Boland, and A. R. de Boland, “Induction of specific proteins in cultured skeletal muscle cells by 1,25-dihydroxyvitamin D-3,” Biochimica et Biophysica Acta, vol. 1012, no. 1, pp. 16–23, 1989. View at Google Scholar · View at Scopus
  67. I. Nemere and A. W. Norman, “Transcaltachia, vesicular calcium transport, and microtubule-associated calbindin-D(28K): emerging views of 1,25-dihydroxyvitamin D3-mediated intestinal calcium absorption,” Mineral and Electrolyte Metabolism, vol. 16, no. 2-3, pp. 109–114, 1990. View at Google Scholar · View at Scopus
  68. I. Nemere, V. Leathers, and A. W. Norman, “1,25-dihydroxyvitamin D3-mediated intestinal calcium transport. Biochemical identification of lysosomes containing calcium and calcium-binding protein (Calbindin-D(28K)),” Journal of Biological Chemistry, vol. 261, no. 34, pp. 16106–16114, 1986. View at Google Scholar · View at Scopus
  69. Z. Xiaoyu, B. Payal, O. Melissa, and L. P. Zanello, “1α,25(OH)2-vitamin D3 membrane-initiated calcium signaling modulates exocytosis and cell survival,” Journal of Steroid Biochemistry and Molecular Biology, vol. 103, no. 3–5, pp. 457–461, 2007. View at Publisher · View at Google Scholar · View at Scopus
  70. A. Minasyan, T. Keisala, J. Zou et al., “Vestibular dysfunction in vitamin D receptor mutant mice,” Journal of Steroid Biochemistry and Molecular Biology, vol. 114, no. 3–5, pp. 161–166, 2009. View at Publisher · View at Google Scholar · View at Scopus
  71. T. H. J. Burne, J. J. McGrath, D. W. Eyles, and A. Mackay-Sim, “Behavioural characterization of vitamin D receptor knockout mice,” Behavioural Brain Research, vol. 157, no. 2, pp. 299–308, 2005. View at Publisher · View at Google Scholar · View at Scopus
  72. I. Endo, D. Inoue, T. Mitsui et al., “Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors,” Endocrinology, vol. 144, no. 12, pp. 5138–5144, 2003. View at Publisher · View at Google Scholar · View at Scopus
  73. S. Ikegami, M. Kamimura, S. Uchiyama, and H. Kato, “Women with insufficient 25-hydroxyvitamin D without secondary hyperparathyroidism have altered bone turnover and greater incidence of vertebral fractures,” Journal of Orthopaedic Science, vol. 16, no. 5, pp. 573–580, 2011. View at Publisher · View at Google Scholar
  74. O. Sahota, M. K. Mundey, P. San, I. M. Godber, N. Lawson, and D. J. Hosking, “The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis,” Bone, vol. 35, no. 1, pp. 312–319, 2004. View at Publisher · View at Google Scholar · View at Scopus
  75. O. Sahota, T. Masud, P. San, and D. J. Hosking, “Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis,” Clinical Endocrinology, vol. 51, no. 2, pp. 217–221, 1999. View at Publisher · View at Google Scholar · View at Scopus
  76. D. Jesudason, A. G. Need, M. Horowitz, P. D. O'Loughlin, H. A. Morris, and B. E. C. Nordin, “Relationship between serum 25-hydroxyvitamin D and bone resorption markers in vitamin D insufficiency,” Bone, vol. 31, no. 5, pp. 626–630, 2002. View at Publisher · View at Google Scholar · View at Scopus
  77. M. Kogawa, D. M. Findlay, P. H. Anderson et al., “Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption,” Endocrinology, vol. 151, no. 10, pp. 4613–4625, 2010. View at Publisher · View at Google Scholar · View at Scopus
  78. H. Takasu, A. Sugita, Y. Uchiyama et al., “c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs,” Journal of Clinical Investigation, vol. 116, no. 2, pp. 528–535, 2006. View at Publisher · View at Google Scholar · View at Scopus
  79. A. P. Mee, J. A. Hoyland, I. P. Braidman, A. J. Freemont, M. Davies, and E. B. Mawer, “Demonstration of vitamin D receptor transcripts in actively resorbing osteoclasts in bone sections,” Bone, vol. 18, no. 4, pp. 295–299, 1996. View at Publisher · View at Google Scholar · View at Scopus
  80. D. S. Wang, M. Miura, H. Demura, and K. Sato, “Anabolic effects of 1,25-dihydroxyvitamin D3 on osteoblasts are enhanced by vascular endothelial growth factor produced by osteoblasts and by growth factors produced by endothelial cells,” Endocrinology, vol. 138, no. 7, pp. 2953–2962, 1997. View at Publisher · View at Google Scholar · View at Scopus
  81. S. Takeda, T. Yoshizawa, Y. Nagai et al., “Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice,” Endocrinology, vol. 140, no. 2, pp. 1005–1008, 1999. View at Publisher · View at Google Scholar · View at Scopus
  82. R. Masuyama, I. Stockmans, S. Torrekens et al., “Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts,” Journal of Clinical Investigation, vol. 116, no. 12, pp. 3150–3159, 2006. View at Publisher · View at Google Scholar · View at Scopus
  83. L. Fu, T. Tang, Y. Miao, Y. Hao, and K. Dai, “Effect of 1,25-dihydroxy vitamin D3 on fracture healing and bone remodeling in ovariectomized rat femora,” Bone, vol. 44, no. 5, pp. 893–898, 2009. View at Publisher · View at Google Scholar · View at Scopus
  84. P. F. Brumbaugh, D. P. Speer, and M. J. Pitt, “1α,25-dihydroxyvitamin D3. A metabolite of vitamin D that promotes bone repair,” American Journal of Pathology, vol. 106, no. 2, pp. 171–179, 1982. View at Google Scholar · View at Scopus
  85. A. D. Delgado-Martinez, M. E. Martinez, M. T. Carrascal, M. Rodriguez-Avial, and L. Munuera, “Effect of 25-OH-vitamin D on fracture healing in elderly rats,” Journal of Orthopaedic Research, vol. 16, no. 6, pp. 650–653, 1998. View at Publisher · View at Google Scholar · View at Scopus
  86. A. M. Doetsch, J. Faber, N. Lynnerup, I. Wätjen, H. Bliddal, and B. Danneskiold-Samsøe, “The effect of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture: a randomized placebo-controlled study,” Calcified Tissue International, vol. 75, no. 3, pp. 183–188, 2004. View at Publisher · View at Google Scholar · View at Scopus
  87. R. U. Simpson, G. A. Thomas, and A. J. Arnold, “Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle,” Journal of Biological Chemistry, vol. 260, no. 15, pp. 8882–8891, 1985. View at Google Scholar · View at Scopus
  88. H. A. Bischoff, M. Borchers, F. Gudat et al., “In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue,” Histochemical Journal, vol. 33, no. 1, pp. 19–24, 2001. View at Publisher · View at Google Scholar · View at Scopus
  89. E. M. Costa, H. M. Blau, and D. Feldman, “1,25-dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells,” Endocrinology, vol. 119, no. 5, pp. 2214–2220, 1986. View at Google Scholar · View at Scopus
  90. G. Vazquez, A. R. de Boland, and R. Boland, “Stimulation of Ca2+ release-activated Ca2+ channels as a potential mechanism involved in non-genomic 1,25(OH)2-vitamin D3-induced Ca2+ entry in skeletal muscle cells,” Biochemical and Biophysical Research Communications, vol. 239, no. 2, pp. 562–565, 1997. View at Publisher · View at Google Scholar · View at Scopus
  91. A. R. de Boland, S. Gallego, and R. Boland, “Effects of vitamin D-3 on phosphate and calcium transport across and composition of skeletal muscle plasma cell membranes,” Biochimica et Biophysica Acta, vol. 733, no. 2, pp. 264–273, 1983. View at Publisher · View at Google Scholar · View at Scopus
  92. L. Drittanti, A. R. de Boland, and R. Boland, “Stimulation of calmodulin synthesis in proliferating myoblasts by 1,25-dihydroxy-vitamin D3,” Molecular and Cellular Endocrinology, vol. 74, no. 2, pp. 143–153, 1990. View at Publisher · View at Google Scholar · View at Scopus
  93. L. Drittanti, A. R. de Boland, and R. L. Boland, “Effects of 1,25-dihydroxyvitamin D-3 on phospholipid metabolism in chick myoblasts,” Biochimica et Biophysica Acta, vol. 962, no. 1, pp. 1–7, 1988. View at Google Scholar · View at Scopus
  94. D. A. Capiati, G. Vazquez, M. T. Tellez Inon, and R. L. Boland, “Role of protein kinase C in 1,25(OH)2-vitamin D3 modulation of intracellular calcium during development of skeletal muscle cells in culture,” Journal of Cellular Biochemistry, vol. 77, no. 2, pp. 200–212, 2000. View at Google Scholar
  95. C. Buitrago, R. Boland, and A. R. de Boland, “The tyrosine kinase c-Src is required for 1,25(OH)2-vitamin D3 signalling to the nucleus in muscle cells,” Biochimica et Biophysica Acta, vol. 1541, no. 3, pp. 179–187, 2001. View at Publisher · View at Google Scholar · View at Scopus
  96. S. Morelli, C. Buitrago, G. Vazquez, A. R. de Boland, and R. Boland, “Involvement of tyrosine kinase activity in 1α,25(OH)2-vitamin D3 signal transduction in skeletal muscle cells,” Journal of Biological Chemistry, vol. 275, no. 46, pp. 36021–36028, 2000. View at Publisher · View at Google Scholar · View at Scopus
  97. C. G. Buitrago, N. S. Arango, and R. L. Boland, “1α, 25(OH)2D3-dependent modulation of Akt in proliferating and differentiating C2C12 skeletal muscle cells,” Journal of Cellular Biochemistry, vol. 113, no. 4, pp. 1170–1181, 2012. View at Publisher · View at Google Scholar
  98. Y. Al-Said, H. Al-Rached, H. Al-Qahtani, and M. Jan, “Severe proximal myopathy with remarkable recovery after vitamin D treatment,” Canadian Journal of Neurological Sciences, vol. 36, no. 3, pp. 336–339, 2009. View at Google Scholar · View at Scopus
  99. H. Glerup, K. Mikkelsen, L. Poulsen et al., “Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement,” Calcified Tissue International, vol. 66, no. 6, pp. 419–424, 2000. View at Publisher · View at Google Scholar · View at Scopus
  100. K. Ekbom, R. Hed, L. Kirstein, and K. E. Astroem, “Weakness of proximal limb muscles, probably due to myopathy after partial gastrectomy. Preliminary report,” Acta Medica Scandinavica, vol. 176, pp. 493–496, 1964. View at Google Scholar · View at Scopus
  101. J. W. Prineas, A. S. Mason, and R. A. Henson, “Myopathy in metabolic bone disease,” British Medical Journal, vol. 1, no. 5441, pp. 1034–1036, 1965. View at Publisher · View at Google Scholar
  102. D. N. Golding, “Muscle pain and wasting in osteomalacia,” Journal of the Royal Society of Medicine, vol. 78, no. 6, pp. 495–496, 1985. View at Google Scholar · View at Scopus
  103. A. J. Reginato, G. F. Falasca, R. Pappu, B. McKnight, and A. Agha, “Musculoskeletal manifestations of osteomalacia: report of 26 cases and literature review,” Seminars in Arthritis and Rheumatism, vol. 28, no. 5, pp. 287–304, 1999. View at Publisher · View at Google Scholar · View at Scopus
  104. K. Ekbom, R. Hed, L. Kirstein, and K. E. Astroem, “Myopathy in metabolic bone disease,” British Medical Journal, vol. 1, no. 5451, pp. 1670–1671, 1965. View at Google Scholar · View at Scopus
  105. J. K. Dhesi, L. M. Bearne, C. Moniz et al., “Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status,” Journal of Bone and Mineral Research, vol. 17, no. 5, pp. 891–897, 2002. View at Google Scholar · View at Scopus
  106. M. Visser, D. J. H. Deeg, and P. Lips, “Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 12, pp. 5766–5772, 2003. View at Publisher · View at Google Scholar · View at Scopus
  107. J. F. J. B. Nellen, Y. M. Smulders, P. H. J. Frissen, E. H. Slaats, and J. Silberbusch, “Hypovitaminosis D in immigrant women: slow to be diagnosed,” British Medical Journal, vol. 312, no. 7030, pp. 570–572, 1996. View at Google Scholar · View at Scopus
  108. J. Mytton, A. P. Frater, G. Oakley, E. Murphy, M. J. Barber, and S. Jahfar, “Vitamin D deficiency in multicultural primary care: a case series of 299 patients,” British Journal of General Practice, vol. 57, no. 540, pp. 577–579, 2007. View at Google Scholar · View at Scopus
  109. G. de Torrenté de La Jara, A. Pécoud, and B. Favrat, “Female asylum seekers with musculoskeletal pain: the importance of diagnosis and treatment of hypovitaminosis D,” BMC Family Practice, vol. 7, article 4, 2006. View at Publisher · View at Google Scholar · View at Scopus
  110. O. H. Sorensen, B. Lund, B. Saltin et al., “Myopathy in bone loss of ageing: improvement by treatment with 1α-hydroxycholecalciferol and calcium,” Clinical Science, vol. 56, no. 2, pp. 157–161, 1979. View at Google Scholar · View at Scopus
  111. H. A. Bischoff, H. B. Stähelin, W. Dick et al., “Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial,” Journal of Bone and Mineral Research, vol. 18, no. 2, pp. 343–351, 2003. View at Publisher · View at Google Scholar · View at Scopus
  112. F. M. Gloth III, C. E. Smith, B. W. Hollis, and J. D. Tobin, “Functional improvement with vitamin D replenishment in a cohort of frail, vitamin D-deficient older people,” Journal of the American Geriatrics Society, vol. 43, no. 11, pp. 1269–1271, 1995. View at Google Scholar · View at Scopus
  113. L. Ceglia, “Vitamin D and its role in skeletal muscle,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 6, pp. 628–633, 2009. View at Publisher · View at Google Scholar · View at Scopus
  114. Y. Sato, J. Iwamoto, T. Kanoko, and K. Satoh, “Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial,” Cerebrovascular Diseases, vol. 20, no. 3, pp. 187–192, 2005. View at Publisher · View at Google Scholar · View at Scopus
  115. M. Pfeifer, B. Begerow, H. W. Minne et al., “Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis,” Experimental and Clinical Endocrinology and Diabetes, vol. 109, no. 2, pp. 87–92, 2001. View at Publisher · View at Google Scholar · View at Scopus
  116. M. Z. Erkal, J. Wilde, Y. Bilgin et al., “High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors,” Osteoporosis International, vol. 17, no. 8, pp. 1133–1140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  117. W. Ahmed, N. Khan, C. J. Glueck et al., “Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients,” Translational Research, vol. 153, no. 1, pp. 11–16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  118. A. W. M. Fok and T. P. Ng, “Osteomalacia: a case series of patients with atypical clinical orthopaedic presentations,” Hong Kong Medical Journal, vol. 16, no. 6, pp. 476–479, 2010. View at Google Scholar · View at Scopus
  119. M. K. Turner, W. M. Hooten, J. E. Schmidt, J. L. Kerkvliet, C. O. Townsend, and B. K. Bruce, “Prevalence and clinical correlates of vitamin D inadequacy among patients with chronic pain,” Pain Medicine, vol. 9, no. 8, pp. 979–984, 2008. View at Publisher · View at Google Scholar · View at Scopus
  120. H. Badsha, M. Daher, and K. Ooi Kong, “Myalgias or non-specific muscle pain in Arab or Indo-Pakistani patients may indicate vitamin D deficiency,” Clinical Rheumatology, vol. 28, no. 8, pp. 971–973, 2009. View at Publisher · View at Google Scholar · View at Scopus
  121. S. E. Tague, G. L. Clarke, M. K. Winter, K. E. McCarson, D. E. Wright, and P. G. Smith, “Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation,” The Journal of Neuroscience, vol. 31, no. 39, pp. 13728–13738, 2011. View at Publisher · View at Google Scholar
  122. S. E. Tague and P. G. Smith, “Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: modulation by ovarian hormones,” Journal of Chemical Neuroanatomy, vol. 41, no. 1, pp. 1–12, 2011. View at Publisher · View at Google Scholar · View at Scopus
  123. T. Akamaru, D. Suh, S. D. Boden, H. S. Kim, A. Minamide, and J. Louis-Ugbo, “Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion,” Spine, vol. 28, no. 5, pp. 429–434, 2003. View at Publisher · View at Google Scholar · View at Scopus
  124. T. Nakajima, H. Iizuka, S. Tsutsumi, M. Kayakabe, and K. Takagishi, “Evaluation of posterolateral spinal fusion using mesenchymal stem cells: differences with or without osteogenic differentiation,” Spine, vol. 32, no. 22, pp. 2432–2436, 2007. View at Publisher · View at Google Scholar · View at Scopus
  125. G. Cinotti, A. Corsi, B. Sacchetti, M. Riminucci, P. Bianco, and G. Giannicola, “Bone ingrowth and vascular supply in experimental spinal fusion with platelet-rich plasma,” Spine, vol. 38, no. 5, pp. 385–391, 2013. View at Publisher · View at Google Scholar
  126. C. P. Dipaola, J. E. Bible, D. Biswas, M. Dipaola, J. N. Grauer, and G. R. Rechtine, “Survey of spine surgeons on attitudes regarding osteoporosis and osteomalacia screening and treatment for fractures, fusion surgery, and pseudoarthrosis,” Spine Journal, vol. 9, no. 7, pp. 537–544, 2009. View at Publisher · View at Google Scholar · View at Scopus