Table of Contents
ISRN Pharmacology
Volume 2013, Article ID 473059, 7 pages
http://dx.doi.org/10.1155/2013/473059
Research Article

A Scientific Validation of Antihyperglycemic and Antihyperlipidemic Attributes of Trichosanthes dioica

1Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad 211 002, India
2Department of NMR, All India Institute of Medical Sciences, New Delhi 110 029, India
3School of Vocational Studies and Applied Chemistry, Gautam Buddha University, Greater Noida, Uttar Pradesh 201310, India

Received 6 June 2013; Accepted 27 June 2013

Academic Editors: D. K. Miller, F. J. Miranda, and R. Villalobos-Molina

Copyright © 2013 Prashant Kumar Rai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was undertaken to scientifically validate the antidiabetic activity of aqueous fruit extract of Trichosanthes dioica Roxb. (Family: Cucurbitaceae) which has been traditionally used for managing diabetes mellitus. This plant commonly known as “Sespadula” in English has not been explored scientifically so far for its glycemic potential except by our research group. The study was conducted with variable doses on normal, mild, and severe diabetics models, and several biochemical parameters including blood glucose level (BGL) were assessed. Maximum fall in BGL of 23.8% in normal rats and of 31.3% in mild diabetic rats was observed during their fasting blood glucose (FBG) and glucose tolerance test (GTT) with the dose of 1000 mg kg−1. In severely diabetic animals after 4 weeks treatment with FBG, postprandial glucose, total cholesterol, and triglyceride levels were reduced by 28.7, 30.7, 57.2, and 18.5%, whereas high density lipoprotein, total protein, hemoglobin, and body weight were increased by 33.0, 36.7, 15.7 and 16.7%, respectively. Moreover, urine sugar was reduced from +4 to +1. Thus, the study scientifically validates the traditional use of T. diocia in diabetes management and could be developed as an effective oral agent for treating diabetes mellitus and complications associated with it.