Figure 3: Schematic structure of a conventional and the four otosclerosis-associated CD46 protein variants. Abbreviations: N-N: terminal of CD46; C-C: terminal of CD46; CCP: complement control protein region; SCR-1 and SCR-2: short consensus repeats 1 and 2; STP-Serine: threonine-proline rich region; U: region of unknown significance; TM: transmembrane domain; CYT2 and CYT3: cytoplasmic domain 2 and 3.