Table of Contents
ISRN Pharmacology
Volume 2013 (2013), Article ID 484675, 10 pages
http://dx.doi.org/10.1155/2013/484675
Research Article

In Vivo and In Vitro Antidiabetic Activity of Terminalia paniculata Bark: An Evaluation of Possible Phytoconstituents and Mechanisms for Blood Glucose Control in Diabetes

KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore-641048, Tamil Nadu, India

Received 30 April 2013; Accepted 3 June 2013

Academic Editors: G. Biala, M. Brunner, and T. W. Stone

Copyright © 2013 Subramaniam Ramachandran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Davis, “Insulin, oral hypoglycemic agents and the pharmacology of the endocrine pancreas,” in The Pharmacological Basis of Therapeutics, L. Brunton, J. Lazo, and K. Parker, Eds., p. 1613, McGraw-Hill, New York, NY, USA, 2006. View at Google Scholar
  2. S. Dewanjee, A. K. Das, R. Sahu, and M. Gangopadhyay, “Antidiabetic activity of Diospyros peregrina fruit: effect on hyperglycemia, hyperlipidemia and augmented oxidative stress in experimental type 2 diabetes,” Food and Chemical Toxicology, vol. 47, no. 10, pp. 2679–2685, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Lin and Z. Sun, “Current views on type 2 diabetes,” Journal of Endocrinology, vol. 204, no. 1, pp. 1–11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. R. S. Gray, R. R. Fabsitz, L. D. Cowan, E. T. Lee, B. V. Howard, and P. J. Savage, “Risk factor clustering in the insulin resistance syndrome. The strong heart study,” American Journal of Epidemiology, vol. 148, no. 9, pp. 869–878, 1998. View at Google Scholar · View at Scopus
  5. W. A. Oranje and B. H. R. Wolffenbuttel, “Lipid peroxidation and atherosclerosis in type II diabetes,” Journal of Laboratory and Clinical Medicine, vol. 134, no. 1, pp. 19–32, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. P. K. Mukherjee, K. Maiti, K. Mukherjee, and P. J. Houghton, “Leads from Indian medicinal plants with hypoglycemic potentials,” Journal of Ethnopharmacology, vol. 106, no. 1, pp. 1–28, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. A. K. Tiwari and J. M. Rao, “Diabetes mellitus and multiple therapeutic approaches of phytochemicals: present status and future prospects,” Current Science, vol. 83, no. 1, pp. 30–38, 2002. View at Google Scholar · View at Scopus
  8. P. S. Varier, Indian Medicinal Plants Compendium of 500 Species, Orient Longman, New Delhi, India, 1995.
  9. B. R. Eesha, A. V. Mohanbabu, K. K. Meena et al., “Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats,” Asian Pacific Journal of Tropical Medicine, vol. 4, no. 6, pp. 466–469, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Talwar, K. Nandakumar, P. G. Nayak et al., “Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflammation in rats,” Journal of Ethnopharmacology, vol. 134, no. 2, pp. 323–328, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Ramachandran, A. Rajasekaran, and K. Manisenthilkumar, “Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats,” Asian Pacific Journal of Tropical Biomedicine, vol. 2, no. 4, pp. 262–268, 2012. View at Publisher · View at Google Scholar
  12. E. K. D. Kumar and G. R. Janardhana, “Antidiabetic activity of alcoholic stem extract of Nervilia plicata in streptozotocin-nicotinamide induced type 2 diabetic rats,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 480–483, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. H.-S. Wu, D.-F. Zhu, C.-X. Zhou et al., “Insulin sensitizing activity of ethyl acetate fraction of Acorus calamus L. in vitro and in vivo,” Journal of Ethnopharmacology, vol. 123, no. 2, pp. 288–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Kuppusamy, U. Muthusamy, S. Andichetiar Thirumalaisamy, S. Varadharajan, K. Ramasamy, and S. Ramanathan, “In vitro (α-glucosidase and α-amylase inhibition) and in vivo antidiabetic property of phytic acid (IP6) in streptozotocin-nicotinamide- induced type 2 diabetes mellitus (NIDDM) in rats,” Journal of Complementary and Integrative Medicine, vol. 8, no. 1, article 9, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Srinivasan and P. Ramarao, “Animal models in type 2 diabetes research: an overview,” Indian Journal of Medical Research, vol. 125, no. 3, pp. 451–472, 2007. View at Google Scholar · View at Scopus
  16. T. Szkudelski, “The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas,” Physiological Research, vol. 50, no. 6, pp. 537–546, 2001. View at Google Scholar · View at Scopus
  17. S. S. Ibrahim and S. M. Rizk, “Nicotinamide: a cytoprotectant against streptozotocin induced diabetic damage in Wistar rat brains,” African Journal of Biochemistry and Research, vol. 2, no. 8, pp. 174–180, 2008. View at Google Scholar
  18. C. Castaneda, “Muscle wasting and protein metabolism,” Journal of Animal Science, vol. 80, supplement 2, pp. E98–E105, 2002. View at Google Scholar
  19. K. M. Uttra, B. R. Devrajani, S. Z. A. Shah et al., “Lipid profile of patients with diabetes mellitus (a multidisciplinary study),” World Applied Sciences Journal, vol. 12, no. 9, pp. 1382–1384, 2011. View at Google Scholar
  20. A. D. Mooradian, “Dyslipidemia in type 2 diabetes mellitus,” Nature Clinical Practice Endocrinology and Metabolism, vol. 5, no. 3, pp. 150–159, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Deguchi and K. Miyazaki, “Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract,” Nutrition and Metabolism, vol. 7, article 9, pp. 1–10, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Calisti and S. Tognetti, “Measure of glycosylated hemoglobin,” Acta Biomedica de l'Ateneo Parmense, vol. 76, supplement 3, pp. 59–62, 2005. View at Google Scholar · View at Scopus
  23. G. M. Brenner and C. W. Stevens, Pharmacology, Saunders, Philadelphia, Pa, USA, 2006.
  24. G. Reaven, F. Abbasi, and T. McLaughlin, “Obesity, insulin resistance, and cardiovascular disease,” Recent Progress in Hormone Research, vol. 59, pp. 207–223, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. H. P. Rang, M. M. Dale, J. M. Ritter, and R. Flower, Pharmacology, Churchill Livingstone, Philadelphia, Pa, USA, 2007.
  26. V. R. Punithavathi, P. S. M. Prince, R. Kumar, and J. Selvakumari, “Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats,” European Journal of Pharmacology, vol. 650, no. 1, pp. 465–471, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. R. C. R. Latha and P. Daisy, “Insulin-secretagogue, antihyperlipidemic and other protective effects of gallic acid isolated from Terminalia bellerica Roxb. in streptozotocin-induced diabetic rats,” Chemico-Biological Interactions, vol. 189, no. 1-2, pp. 112–118, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. C. N. Vishnu Prasad, T. Anjana, A. Banerji, and A. Gopalakrishnapillai, “Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells,” The FEBS Letters, vol. 584, no. 3, pp. 531–536, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. Sameermahmood, L. Raji, T. Saravanan, A. Vaidya, V. Mohan, and M. Balasubramanyam, “Gallic acid protects RINm5F β-cells from glucolipotoxicity by its antiapoptotic and insulin-secretagogue actions,” Phytotherapy Research, vol. 24, no. 1, pp. S83–S94, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Pitchai and R. Manikkam, “Hypoglycemic and insulin mimetic impact of catechin isolated from Cassia fistula: a substantiate in silico approach through docking analysis,” Medicinal Chemistry Research, vol. 21, pp. 2238–2250, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. A. M. Griffith (Tucker), Inhibition of α-amylase and α-glucosidase by bioflavonoids [Baccalureate of Science Thesis], Oregon State University, University Honors College, Corvallis, Ore, USA, 2012, http://ir.library.oregonstate.edu/xmlui/handle/1957/29953?show=full.
  32. C. F. Huang, Y. W. Chen, C. Y. Yang et al., “Extract of lotus leaf (Nelumbo nucifera) and its active constituent catechin with insulin secretagogue activity,” Journal of Agricultural and Food Chemistry, vol. 59, no. 4, pp. 1087–1094, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Ueda, T. Furuyashiki, K. Yamada et al., “Tea catechins modulate the glucose transport system in 3T3-L1 adipocytes,” Food and Function, vol. 1, no. 2, pp. 167–173, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Ahmad, P. Khalid, M. M. Khan, A. K. Rastogi, and J. R. Kidwai, “Insulin like activity in (-) epicatechin,” Acta Diabetologica Latina, vol. 26, no. 4, pp. 291–300, 1989. View at Google Scholar · View at Scopus
  35. P. Malini, G. Kanchana, and M. Rajadurai, “Antiperoxidative and antioxidant effect of ellagic acid on normal and streptozotocin induced diabetes in albino Wistar rats,” Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 2, no. 3, pp. 24–34, 2011. View at Google Scholar · View at Scopus