Table of Contents
ISRN Obesity
Volume 2013, Article ID 490923, 8 pages
Research Article

Relationship between Birth Weight and Metabolic Status in Obese Adolescents

1London Health Sciences Centre, Lawson Health Research Institute, London, ON, Canada N6A 5W9
2Lawson Health Research Institute, St Joseph's Health Care, 268 Grosvenor Street, London, ON, Canada N6A 4V2
3Department of Paediatrics, University of Western Ontario, London, ON, Canada N6A 5A5
4Department of Medicine, University of Western Ontario, London, ON, Canada N6A 5A5
5Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5A5
6School of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5
7London Health Sciences Centre, Children’s Hospital, London, ON, Canada N6A 5W9
8Department of Pediatrics , University of Calgary, Calgary, Alberta, Canada
9Department of Paediatrics, University of Toronto and Hospital for Sick Children, Toronto, ON, Canada M5G 1X8

Received 13 June 2013; Accepted 28 July 2013

Academic Editors: A. Erkner, B. Navia, and R. Tungtrongchitr

Copyright © 2013 David J. Hill et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To examine the relationships between birth weight and body mass index, percent body fat, blood lipids, glycemia, insulin resistance, adipokines, blood pressure, and endothelial function in a cohort of obese adolescents. Design and Methods. Ninety-five subjects aged 10–16 years (mean age 13.5 years) with a body mass index >95th centile (mean [±SEM] 33.0 ± 0.6) were utilized from two prospective studies for obesity prevention prior to any interventions. The mean term birth weight was 3527 ± 64 g (range 1899–4990 g;). Results. Body mass index z-score correlated positively with birth weight ( , ), but not percent body fat. Insulin resistance negatively correlated with birth weight ( , ), as did fasting plasma insulin ( , ); both being significantly greater for subjects of small versus large birth weight (Δ Homeostasis Model Assessment = 2.5 and Δ insulin = 10 pmol/L for birth weight <2.5 kg versus >4.5 kg). Adiponectin, but not leptin, blood pressure z-scores or peripheral arterial tomography values positively correlated with birth weight ( , ). Conclusions. Excess body mass index in obese adolescents was positively related to birth weight. Birth weight was not associated with cardiovascular risk factors but represented a significant determinant of insulin resistance.