Table of Contents
ISRN Medicinal Chemistry
Volume 2013, Article ID 492604, 8 pages
Research Article

Regioselective Synthesis of Dispiro Pyrrolizidines as Potent Antimicrobial Agents for Human Pathogens

Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India

Received 24 June 2013; Accepted 18 July 2013

Academic Editors: C.-Y. Gong and L. Soulère

Copyright © 2013 N. Sirisha and R. Raghunathan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Synthesis of a series of novel dispiro pyrrolizidines has been accomplished by 1,3-dipolar cycloaddition reaction of azomethine ylide generated from secondary amino acids and diketones with bischalcones. These compounds were evaluated for their antibacterial activity. Most of the synthetic compounds exhibited good antibacterial activity against microorganisms.