Midkine Mediates Intercellular Crosstalk between Drug-Resistant and Drug-Sensitive Neuroblastoma Cells In Vitro and In Vivo

Table 2

Midkine expression prechemotherapy compared to postchemotherapy.

	Nuclear Score			Cytoplasmic score
	Pre-chemo	Post-chemo	𝑃	Pre-chemo	Post-chemo	𝑃
All biopsies*	2.3±1.1	1.7±1.2	0.15	0.9±1.1	2.2±1.3	0.005
Matched biopsies**	2.1±1.3	1.9±1.3	0.74	0.4±0.8	2.3±1.2	<0.001

∗Comparison based on 20 prechemotherapy biopsies and 12 postchemotherapy biopsies.
**Comparison based only on the 10 patients with matched pre- and postchemotherapy biopsies available for analysis.