Table of Contents
ISRN Biomathematics
Volume 2013 (2013), Article ID 534891, 6 pages
Research Article

Total Variation Filtered Demons for Improved Registration of Sliding Organs

1Department of Electrical and Computer Engineering, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina
2Medical Image Analysis Center, University of Basel, 4031 Basel, Switzerland

Received 16 September 2013; Accepted 10 November 2013

Academic Editors: J. Chow and X. Wan

Copyright © 2013 Damir Demirović et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present a new approach to regularize the displacement field of the accelerated Demons registration algorithm. The accelerated Demons algorithm uses Gaussian smoothing to penalize oscillatory motion in the displacement fields during registration. This regularization approach is often applied and ensures a smooth deformation field. However, when registering images with discontinuities in their motion field such as from organs sliding along the chest wall, the assumption of a smooth deformation field is invalid. In this work, we propose using total variation based smoothing that is known to better retain the discontinuities in the deformation field. The proposed approach is a first step towards automatically recovering breathing induced organ motion with good accuracy.