Table of Contents
ISRN Inorganic Chemistry
Volume 2013, Article ID 562082, 7 pages
Research Article

Synthesis, Characterization, and Biological and Cytotoxic Studies of Copper(II), Nickel(II), and Zinc(II) Binary Complexes of 3-Amino-5-methyl Isoxazole Schiff Base

1Department of Chemistry, Osmania University, Hyderabad, Andhra Pradesh 500 007, India
2Department of Chemistry, University College of Technology, Osmania University, Hyderabad, Andhra Pradesh 500 007, India
3Department of Chemistry, Mahatma Gandhi University, Nalgonda, Andhra Pradesh 508 254, India

Received 1 October 2012; Accepted 26 November 2012

Academic Editors: M. Koman and O. Z. Yesilel

Copyright © 2013 K. Sathish Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Binary complexes of Cu(II), Ni(II), and Zn(II) ions have been synthesized by reacting metal salts with a Schiff base, 2-((E)-(5-methylisoxazol-3-ylimino)methyl)-4-methoxyphenol (MIIMMP) in an alcoholic medium. All the metal complexes and schiff base have been characterized by using elemental analysis, IR, UV-VIS, 1H-NMR, 13C-NMR, Mass, ESR spectral data, magnetic moments, TG, and DTA studies. Based on the analytical, spectral data and molecular modeling studies, Ni(II) and Zn(II) metal complexes have octahedral geometry, whereas Cu(II) complex has tetragonal geometry. The antimicrobial and cytotoxic activities of the Schiff base and its metal complexes were studied on bacteria, fungi, and human cervical carcinoma cells (HeLa).