International Scholarly Research Notices / 2013 / Article / Fig 4

Review Article

Cell Transplantation and “Stem Cell Therapy” in the Treatment of Myopathies: Many Promises in Mice, Few Realities in Humans

Figure 4

Exogenous satellite cells are formed by the transplantation of human myoblasts in immunodeficient mice. The figure shows a single myofiber in a cross-section of a skeletal muscle of an immunodeficient mouse transplanted with myoblasts from an adult human donor 4 weeks before. Different elements are evidenced by fluorescent immunodetection in confocal microscopy. The peripheral nuclear labeling of human lamin A/C (green fluorescence) evidenced human nuclei in the periphery of the myofiber (visible by contrast enhancement). One of them (arrows) shows a typical intranuclear staining of Pax7, a marker of satellite cells (red fluorescence). Immunodetection of laminin (blue fluorescence) evidenced that this nucleus is in addition in the periphery of the myofiber and inside the basal lamina, that is, in the anatomical position of satellite cells (see Figure 5). Scale bar = 10 μm.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.