Changes in the Bispectral Index in Response to Experimental Noxious Stimuli in Adults under General Anesthesia
Table 4
Sensitivity and specificity at different BIS values.
Criterion
Sensitivity
95% CI
Specificity
95% CI
≥16
100.00
88.4–100.0
0.00
0.0–11.6
>16
96.67
82.8–99.9
0.00
0.0–11.6
>19
96.67
82.8–99.9
3.33
0.08–17.2
>24
86.67
69.3–96.2
3.33
0.08–17.2
>25
83.33
65.3–94.4
10.00
2.1–26.5
>26
80.00
61.4–92.3
20.00
7.7–38.6
>27
80.00
61.4–92.3
23.33
9.9–42.3
>28
73.33
54.1–87.7
23.33
9.9–42.3
>29
70.00
50.6–85.3
26.67
12.3–45.9
>31
70.00
50.6–85.3
33.33
17.3–52.8
>34
56.67
37.4–74.5
33.33
17.3–52.8
>36
56.67
37.4–74.5
36.67
19.9–56.1
>38
50.00
31.3–68.7
40.00
22.7–59.4
>41
50.00
31.3–68.7
56.67
37.4–74.5
>42
43.33
25.5–62.6
63.33
43.9–80.1
>43
40.00
22.7–59.4
66.67
47.2–82.7
>45*
40.00
22.7–59.4
73.33
54.1–87.7
>46
26.67
12.3–45.9
80.00
61.4–92.3
>47
26.67
12.3–45.9
86.67
69.3–96.2
>48
23.33
9.9–42.3
90.00
73.5–97.9
>49
16.67
5.6–34.7
90.00
73.5–97.9
>50
16.67
5.6–34.7
93.33
77.9–99.2
>51
13.33
3.8–30.7
93.33
77.9–99.2
>53
13.33
3.8–30.7
96.67
82.8–99.9
>54
6.67
0.8–22.1
100.00
88.4–100.0
>58
0.00
0.0–11.6
100.00
88.4–100.0
Sensitivity and specificity of BIS in distinguishing moderate from severe noxious stimuli at different thresholds of BIS (criterion) with 95% confidence intervals. >: superior; <: inferior; CI: confidence interval.
*Best cut-off ROC score. Threshold associated with maximization of the sums of sensitivity and specificity.
