Age-Related Differences in Response to High-Fat Feeding on Adipose Tissue and Metabolic Profile in ZDSD Rats

Table 1

Body composition and AT morphology in ZDSD rats fed HFD beginning at 63, 84, and 112 d after parturition.

	LFD	HFD 63 d	HFD 84 d	HFD 112 d
Body weight (g)	531 ± 27.4	514 ± 27.4	454 ± 27.4	480 ± 27.4
Fat mass^†	14.8 ± 2.54^a	23.0 ± 2.54^b	14.8 ± 2.54^a	14.3 ± 2.54^a
Lean mass^†	70.2 ± 1.79^a	62.5 ± 1.79^b	69.3 ± 1.79^a	69.2 ± 1.79^a
Water mass^†	59.2 ± 2.35	55.3 ± 2.35	58.0 ± 2.35	57.9 ± 2.35
Subcutaneous adipocyte^‡
Area (𝜇m^2)	8318 ± 807^ab	10009 ± 931^b	6360 ± 807^a	6869 ± 807^a
Number	371 ± 76.7^a	647 ± 88.5^b	288 ± 76.7^a	266 ± 76.7^a
Epididymaladipocyte^‡
Adipocyte area (𝜇m^2)	9368 ± 1131^ab	11356 ± 1131^b	8530 ± 1131^a	8520 ± 1131^a
Number	149 ± 40.3^a	270 ± 40.3^b	137 ± 43.3^a	128 ± 43.3^a

∗Letters represent significant differences among means as determined by post hoc comparison (𝑃<0.05).
†Data presented as percent of total body weight.
‡Determined by analysis of fixed area on H & E stained slides.