Clinical Study

Effect of Telmisartan on Cerebral and Systemic Haemodynamics in Patients with Recent Ischaemic Stroke: A Randomised Controlled Trial

Table 2

Baseline haemodynamic measures. Mean (standard deviation) number of subjects.

CharacteristicTelmisartanPlacebo

Blood pressure (mmHg) versus 7
 Systolic BP168.1 (21.3)157.7 (21.4)
 Mean arterial BP117.4 (14.6)113.1 (14.2)
 Diastolic BP91.6 (16.8)90.9 (12.4)
 Heart rate (bpm)69.6 (15.8)74.6 (14.6)
Cerebral blood flow, ipsilateral hemisphere (mL/min/100 g) versus 7
 Global42.2 (13.5)47.3 (20.9)
 Hemispheric42.1 (14.3)45.7 (19.7)
 Anterior cerebral artery42.0 (13.2)45.4 (25.7)
 Middle cerebral artery48.1 (23.3)45.5 (20.3)
 Posterior cerebral artery44.6 (18.9)47.8 (24.9)
Cerebral blood flow, contralateral hemisphere (mL/min/100 g) versus 7
 Global
 Hemispheric42.6 (12.8)50.1 (22.8)
 Anterior cerebral artery48.2 (16.5)49.2 (27.1)
 Middle cerebral artery49.1 (18.4)53.3 (23.8)
 Posterior cerebral artery42.4 (12.6)44.8 (23.9)
Lesion area (pixels) versus 7
 Total1102 (884)1082 (688)
 Oligaemia240 (146)237 (176)
 Penumbra200 (302)162 (190)
 Core268 (511)264 (561)
Transcranial doppler measures, ipsilateral versus 5
 Systolic cerebral blood flow
 velocity (cm/s)
65.9 (20.1)51.2 (16.3)
 Pulsatility index1.06 (0.20)1.08 (0.21)
 Cerebral perfusion pressure66.8 (14.2)58.6 (13.6)
 Zero filling pressure48.3 (16.3)58.1 (3.2)