Clinical Study

Effect of Telmisartan on Cerebral and Systemic Haemodynamics in Patients with Recent Ischaemic Stroke: A Randomised Controlled Trial

Table 3

Effect of telmisartan on haemodynamic measures at four hours.

MeasurementControl ( )Telmisartan ( )Control (mean/sd)Telmisartan (mean/sd)Difference ( , 95% CI) value

CBF, mL/min/100 g
 Global6941.4 (10.0)46.3 (10.1)−1.2 (−16.9, 4.6)0.24
 Ipsilateral hemispheric6938.9 (10.4)45.4 (10.6)−1.5 (−17.8, 3.1)0.15
 ACA6948.6 (16.2)50.4 (10.1)−0.3 (−16.5, 12.0)0.74
 MCA6940.2 (11.9)48.7 (10.7)−1.4 (−17.2, 3.7)0.18
 PCA6939.9 (13.1)53.0 (27.2)−1.5 (−37.8, 6.4)0.15
CBF, mL/min/100 g
 Contralateral hemispheric6942.7 (9.4)47.2 (10.2)−1.1 (−17.4, 5.9)0.30
 ACA6956.0 (21.4)55.5 (11.0)0.03 (−18.6, 19.1)0.99
 MCA6946.5 (10.2)49.5 (12.7)−0.7 (−16.9, 8.8)0.51
 PCA6941.8 (12.6)51.2 (15.3)−1.3 (27.0, 6.7)0.21
 Lesion area, pixels691171 (690)1114 (905)−1 (−53, 22)0.38
 Oligaemia69315 (184)273 (183)0 (−141, 193)0.74
 Penumbra69207 (191)154 (183)2 (−21, 146)0.13
 Core69206 (290)139 (213)1 (−68, 171)0.36
TCD ipsilateral
 Systolic CBFv (cm/s)4661.0 (13.0)80.5 (24.0)−0.8 (−33.5, 16.5)0.45
 CPP4661.0 (10.8)56.6 (13.2)0.5 (−16.6, 26.3)0.61
 ZFP4656.8 (16.5)48.5 (9.7)0.9 (−11.8, 26.2)0.40
 Augmentation index7929.3 (10.3)28.4 (12.4)1.1 (−6.0, 17.7)0.31
 Buckberg index79162.4 (38.3)161.7 (35.9)−2.1 (−49.3, 0.8)0.06