Table of Contents
ISRN Microbiology
Volume 2013 (2013), Article ID 601076, 4 pages
http://dx.doi.org/10.1155/2013/601076
Research Article

The Effect of Curcumin and Cotrimoxazole in Salmonella Typhimurium Infection In Vivo

1Laboratory of Microbiology, Faculty of Medicine, Brawijaya University, Jl Veteran Malang 65145, East Java, Indonesia
2Laboratory of Pharmacology, Faculty of Medicine, Brawijaya University, Jl Veteran Malang 65145, East Java, Indonesia

Received 24 June 2013; Accepted 15 July 2013

Academic Editors: T. Krishnan, T. Pusztahelyi, S. J. Taj-Aldeen, and T. P. West

Copyright © 2013 Siwipeni Irmawanti Rahayu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Typhoid fever is a disease caused by Salmonella Typhi and commonly treated by an antimicrobial agent such as cotrimoxazole. On the other hand, herbal usage has risen as an adjunctive therapy to treat many diseases. Curcuma (Curcuma domestica) is a commonly used herb which consists of curcumin as its major active compound. Curcumin has been known for its antimicrobial effect, but there is no proof regarding the usage of curcumin and cotrimoxazole together. This research was conducted by using typhoid fever model in mice infected by Salmonella Typhimurium. Each animal was treated with curcumin, cotrimoxazole, or both. Ileum, spleen, and liver of each animal were isolated and cultured. We found that curcumin-cotrimoxazole combination therapy lowered the antimicrobial effectivity of cotrimoxazole in both intraintestinal and extraintestinal organs. We conclude that curcumin-cotrimoxazole combination therapy in typhoid fever has to be reconsidered.