Table of Contents
ISRN Inorganic Chemistry
Volume 2013, Article ID 604218, 7 pages
http://dx.doi.org/10.1155/2013/604218
Research Article

DNA Interaction Studies of a Cobalt(II) Mixed-Ligand Complex Containing Two Intercalating Ligands: 4,7-Dimethyl-1, 10-Phenanthroline and Dipyrido[3,2-a:-c]phenazine

Department of Chemistry, Faculty of Science, Razi University, Kermanshah 74155, Iran

Received 15 November 2012; Accepted 5 December 2012

Academic Editors: B. F. Ali, V. Barba, A. M. Fonseca, and L. G. Lopes

Copyright © 2013 Nahid Shahabadi and Maryam Mahdavi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new cobalt(II) complex [Co(dppz)2(4,7-dmp)]2+ (4,7-dmp = 4,7-dimethyl-1,10-phenanthrolline) and dppz = dipyrido[3,2-a:2′-3′-c]phenazine has been synthesized and characterized by elemental analysis (CHN), FT-IR, and UV-visible (UV-Vis) spectroscopic techniques. The DNA-binding property of the complex has been investigated employing absorption spectroscopy, fluorescence spectroscopy, circular dichroism, and viscosity measurements. The experimental results show that the complex can bind to DNA in an intercalation mode. In comparison with previous study, the DNA-binding affinity of [Co(dppz)2(4,7-dmp)]2+ ( M−1) is smaller than that of complex [Co(dppz)2(2,9-dmp)]2+ ( M−1).