Figure 1: Highly simplified schematic showing relevant anatomical connectivity of the laterodorsal tegmentum (LDT) within known addiction-related pathways in the rat brain. The LDT contains separate populations of cholinergic, GABAergic, and glutamatergic neurons. A subset of these cells sends projections to the ventral tegmental area (VTA) synapsing on GABAergic and dopamine-containing cells in this nucleus which project to the nucleus accumbens (nAC). The prefrontal cortex (PFC) exerts control over the VTA via direct projections to this nucleus and via an indirect pathway synapsing within the LDT.