Stability Indicating HPTLC Method for Analysis of Rifaximin in Pharmaceutical Formulations and an Application to Acidic Degradation Kinetic Study

Table 1

Linear regression parameters for rifaximin by HPTLC method.

Parameters	Rifaximin
Linearity range^a (ng/band)	400–3200
Correlation coefficient (𝑟^2)	0.999±0.0024
Slope ± SD (𝑆𝑏)	4.83±0.06
Confidence limit of slope^c	4.76–4.91
Intercept ± SD (𝑆𝑎)	309.82±89.70
Confidence limit of intercept^c	197.40–420.18
Limit of detection (ng/band)	61.25
Limit of quantitation (ng/band)	185.59
Bartlett’s test^b (𝜒^2)	0.267

^a𝑛=5 replicates, ^bcalculated value 𝜒² less than critical value 𝜒²_(0.05,5)=9.488, and ^c95% confidence limit.