International Scholarly Research Notices / 2013 / Article / Tab 6

Research Article

Stability Indicating HPTLC Method for Analysis of Rifaximin in Pharmaceutical Formulations and an Application to Acidic Degradation Kinetic Study

Table 6

Degradation study of rifaximin in various conditions.

Exposure conditionsDegradation products ( )Recovery (%)a

None (control sample)Not detected100
0.1 M HCl, refluxed (30 min)0.44, 0.4955.39
0.1 M NaOH, refluxed (30 min)0.46, 0.5181.94
3% Hydrogen peroxide, refluxed (30 min)0.4794.95
Wet heat, refluxed (30 min)100
Sunlight (24 h)0.6789.72
UV light, 254 nm (24 h)0.4998.34

replicates for concentration of 1000 ng/band.

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