Stability Indicating HPTLC Method for Analysis of Rifaximin in Pharmaceutical Formulations and an Application to Acidic Degradation Kinetic Study

Table 7

Degradation rate constant (𝐾_obs), half-life (𝑡_1/2), and shelf life (𝑡₉₀) for rifaximin at various temperatures.

Temp. (K); 0.1 M HCl	𝐾obs (h^−1)	𝑡1/2 (h)	𝑡90 (h)
313	0.00208	5.55	0.84
323	0.00524	2.20	0.33
333	0.01	1.05	0.15
343	0.03	0.41	0.06