Table of Contents
ISRN Organic Chemistry
Volume 2013 (2013), Article ID 616932, 5 pages
Research Article

An Eco-Friendly Improved Protocol for the Synthesis of Bis(3-indolyl)methanes Using Poly(4-vinylpyridinium)hydrogen Sulfate as Efficient, Heterogeneous, and Recyclable Solid Acid Catalyst

1Department of Chemistry, National Institute of Technology, Warangal, Andhra Pradesh 506 004, India
2Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

Received 2 July 2013; Accepted 1 August 2013

Academic Editors: E. Bertounesque, F. C. Pigge, and Z. Wimmer

Copyright © 2013 Janardhan Banothu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Highly efficient and eco-friendly protocol for the synthesis of bis(3-indolyl)methanes by the electrophilic substitution reaction of indole with aldehydes catalyzed by poly(4-vinylpyridinium)hydrogen sulfate was described. Excellent yields, shorter reaction times, simple work-up procedure, avoiding hazardous organic solvents, and reusability of the catalyst are the most obvious advantages of this method.