Research Article
Synthesis and Evaluation of Substituted 4,4a-Dihydro-3H,10H-pyrano[4,3-b][1]benzopyran-10-one as Antimicrobial Agent
Table 1
Reaction time (h) and yield (%) of various purified products.
| Sr. number | | | | | Reaction time (h) | Products yield (%) | endo | exo |
| 1 | H | H | H | O-iBu | 72 | 7a (77) | 8a (traces) | 2 | H | H | CH3 | O-iBu | 72 | 7b (70) | 8b (traces) | 3 | Cl | H | Cl | O-iBu | 36 | 7c (74) | 8c (traces) | 4 | H | H | Cl | O-iBu | 24 | 7d (72) | 8d (traces) | 5 | H | Cl | F | O-iBu | 36 | 7e (78) | 8e (traces) | 6 | H | H | Br | O-iBu | 24 | 7f (71) | 8f (traces) | 7 | H | Br | H | O-iBu | 48 | 7g (73) | 8g (traces) | 8 | H | F | H | O-iBu | 48 | 7h (70) | 8h (traces) | 9 | H | H | F | O-iBu | 72 | 7i (72) | 8i (traces) | 10 | H | Cl | H | O-iBu | 48 | 7j (73) | 8j (traces) | 11 | H | H | H | OEt | 168 | 7k (75) | 8k (traces) | 12 | H | H | CH3 | OEt | 96 | 7l (72) | 8l (traces) | 13 | Cl | H | Cl | OEt | 216 | 7m (73) | 8m (traces) | 14 | H | H | Cl | OEt | 192 | 7n (76) | 8n (traces) | 15 | H | H | F | OEt | 72 | 7o (72) | 8o (traces) | 16 | H | H | Br | OEt | 48 | 7p (74) | 8p (traces) | 17 | H | Br | H | OEt | 96 | 7q (75) | 8q (traces) | 18 | H | F | H | OEt | 120 | 7r (76) | 8r (traces) | 19 | H | Cl | F | OEt | 96 | 7s (74) | 8s (traces) | 20 | H | Cl | H | OEt | 72 | 7t (72) | 8t (traces) |
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