Table of Contents
ISRN Inorganic Chemistry
Volume 2013, Article ID 623962, 6 pages
Research Article

Synthesis, Characterization, and Biological Studies of New Ruthenium Polypyridyl Complexes Containing Noninnocent Ligands

1Department of Chemistry, Faculty of Science, University of Semnan, P.O. Box 35195-363 Semnan, Iran
2Biochemistry Department, Faculty of Medicine, Semnan University of Medical Science, Semnan, Iran

Received 13 November 2012; Accepted 29 November 2012

Academic Editors: B. Sohrabi and B. Yan

Copyright © 2013 Sofia Taheri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Two new polypyridyl complexes [Ru(ttp)(L1)Cl]PF6 (1) and [Ru(ttp)(L2)Cl]PF6 (2) with noninnocent o-benzoquinonediimine (L1; bqdi) and 4,5-dimethyle-o-benzoquinonediimine (L2; 4,5-di-Mebqdi) ligands were synthesized and characterized (ttp = -p-toloyle-2, : , -terpyridine). Cyclic voltammetry studies suggest that noninnocent ligands are coordinated in their benzoquinonediimine form. Preliminary ruthenium complexes-induced DNA dysfunction was studied on E. coli GM109 DNA by means of melting temperature analysis (Tm). Our results suggest that complex (2) inhibited DNA function more strongly compared to (1). Antibacterial activities of the complexes against E. coli bacteria were studied, and Minimum inhibitory concentration (MIC) values were evaluated. Both complexes showed great antibacterial activities.