Table 1: How a genomic susceptibility organizational structure (SOS) may influence progeny responses to environmental exposures.

Generation Evolution of genomic SOS
Chromatin modificationCancer risk


Translation of epigenetic alterations amongst migrant populations from low-risk cancer (breast and prostate) areas to high-risk regions. Parental generation has not acquired a genomic SOS, but by F1 and subsequent generations this organizational structure has emerged via environmental and/or lifestyle changes. This exposes the F2/F3 genomes to DNA damage insult.
−: not present; +: evolving; ++: evolved; +++: highly evolved.