Epigenetic Influences in the Aetiology of Cancers Arising from Breast and Prostate: A Hypothesised Transgenerational Evolution in Chromatin Accessibility

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left" rowspan="2">Generation</td><td align="center" colspan="2">
								Evolution of genomic SOS</td></tr><tr class="thead"><td align="center">Chromatin modification</td><td align="center">Cancer risk</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">F0</td><td align="center">−</td><td align="center">Low</td></tr><tr><td align="left">F1</td><td align="center">+</td><td align="center">Low</td></tr><tr><td align="left">F2</td><td align="center">++</td><td align="center">Emerging</td></tr><tr><td align="left">F3</td><td align="center">+++</td><td align="center">High</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Translation of epigenetic alterations amongst migrant populations from low-risk cancer (breast and prostate) areas to high-risk regions. Parental generation has not acquired a genomic SOS, but by F1 and subsequent generations this organizational structure has emerged <i>via</i> environmental and/or lifestyle changes. This exposes the F2/F3 genomes to DNA damage insult.<br/>−: not present; +: evolving; ++: evolved; +++: highly evolved.<br/></td></tr></table>

How a genomic susceptibility organizational structure (SOS) may influence progeny responses to environmental exposures.

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Table 1

Table 1: Epigenetic Influences in the Aetiology of Cancers Arising from Breast and Prostate: A Hypothesised Transgenerational Evolution in Chromatin Accessibility 

Table 1 | Epigenetic Influences in the Aetiology of Cancers Arising from Breast and Prostate: A Hypothesised Transgenerational Evolution in Chromatin Accessibility 