Caspase-3 and Survivin Expression in Primary Atypical and Malignant Meningiomas

Table 2

Univariate survival analysis of 86 AMM.

Variable	𝑛	Recurrence free survival			Overall survival
		HR	95% CI	𝑃 value	HR	95% CI	𝑃 value
Sex (male versus female)	86	1.9	0.9−4.0	0.077	1.9	1.0−3.8	0.064
Age (≥55 versus <55)	86	0.9	0.5−1.8	0.776	3.19	1.5−6.7	0.002
Location (parasagittal-falcine versus others)	86	2.3	1.1−4.7	0.021	1.5	0.8−3.0	0.238
WHO grade (III versus II)	86	2.0	0.8−5.3	0.145	1.7	0.6−4.3	0.293
Mitotic count (continuous)	86	1.08	1.03−1.13	0.001	1.03	0.99−1.08	0.158
Brain invasion when assessable (present versus absent)	37	7.2	0.9−55.7	0.059	4.4	1.0−19.2	0.049
Ki67 (%)	86	1.00	0.97−1.05	0.701	1.00	0.95−1.03	0.606
Ki67 (>4% versus ≤4%)	86	2.7	1.1−6.7	0.027	1.9	0.9−4.0	0.104
Caspase-3 expression	85	1.0	0.5−2.2	0.375	1.1	0.6−2.1	0.812
Survivin expression	85	0.7	0.3−1.7	0.488	1.0	0.5−2.0	0.994