Table of Contents 
ISRN Nanotechnology
Volume 2013 (2013), Article ID 629510, 5 pages
http://dx.doi.org/10.1155/2013/629510
Review Article

Targeted, Monitored, and Controlled Chemotherapy: A Multimodal Nanotechnology-Based Approach against Cancer

Ali Shakeri-Zadeh,1 Samideh Khoei,1 Sepideh Khoee,2 Ali Mohammad Sharifi,3 and Mohammad-Bagher Shiran1

1Department of Medical Physics, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran 14155-5983, Iran
2School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
3Razi Drug Research Center and Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Received 10 May 2013; Accepted 19 July 2013

Academic Editors: A. Hu and A. Taubert

Copyright © 2013 Ali Shakeri-Zadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Ali Mansoori, K. S. Brandenburg, and A. Shakeri-Zadeh, “A comparative study of two folate-conjugated gold nanoparticles for cancer nanotechnology applications,” Cancers, vol. 2, no. 4, pp. 1911–1928, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Zhang, B. Wang, Y. Wang, W. Qiao, and P. Shao, “A novel hypurgia for cancer chemotherapy: programmable release of antineoplastics and cytothesis agents from core-shell micro-/nano-particles,” Medical Hypotheses, vol. 76, no. 2, pp. 201–203, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. J. R. Senior, “Unintended hepatic adverse events associated with cancer chemotherapy,” Toxicologic Pathology, vol. 38, no. 1, pp. 142–147, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Ciofani, C. Riggio, V. Raffa, A. Menciassi, and A. Cuschieri, “A bi-modal approach against cancer: magnetic alginate nanoparticles for combined chemotherapy and hyperthermia,” Medical Hypotheses, vol. 73, no. 1, pp. 80–82, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Jordan, P. Wust, H. Fahling, W. John, A. Hinz, and R. Felix, “Inductive heating of ferrimagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia,” International Journal of Hyperthermia, vol. 9, no. 1, pp. 51–68, 1993. View at Google Scholar · View at Scopus
  6. J. Siepmann, N. Faisant, J. Akiki, J. Richard, and J. P. Benoit, “Effect of the size of biodegradable microparticles on drug release: experiment and theory,” Journal of Controlled Release, vol. 96, no. 1, pp. 123–134, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Alexiou, R. Jurgons, R. J. Schmid et al., “Magnetic drug targeting—biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment,” Journal of Drug Targeting, vol. 11, no. 3, pp. 139–149, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. A.-J. Lemke, M.-I. Senfft von Pilsach, A. Lübbe, C. Bergemann, H. Riess, and R. Felix, “MRI after magnetic drug targeting in patients with advanced solid malignant tumors,” European Radiology, vol. 14, no. 11, pp. 1949–1955, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Mosbach and U. Schroder, “Preparation and application of magnetic polymers for targeting of drugs,” FEBS Letters, vol. 102, no. 1, pp. 112–116, 1979. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Ashjari, S. Khoee, and A. R. Mahdavian, “A multiple emulsion method for loading 5-fluorouracil into a magnetite-loaded nanocapsule: a physicochemical investigation,” Polymer International, vol. 61, no. 5, pp. 850–859, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. M. B. Shiran, M. Motevalian, R. Ravanfar, and S. Bohlooli, “The effect of bubble surface charge on phonophoresis: implication in transdermal piroxicam delivery,” Iranian Journal of Pharmacology and Therapeutics, vol. 7, no. 1, pp. 15–19, 2008. View at Google Scholar · View at Scopus
  12. I. V. Larina, B. M. Evers, T. V. Ashitkov, C. Bartels, K. V. Larin, and R. O. Esenaliev, “Enhancement of drug delivery in tumors by using interaction of nanoparticles with ultrasound radiation,” Technology in Cancer Research and Treatment, vol. 4, no. 2, pp. 217–226, 2005. View at Google Scholar · View at Scopus
  13. N. Y. Rapoport, D. A. Christensen, H. D. Fain, L. Barrows, and Z. Gao, “Ultrasound-triggered drug targeting of tumors in vitro and in vivo,” Ultrasonics, vol. 42, no. 1–9, pp. 943–950, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Liu, H. Miyoshi, and M. Nakamura, “Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles,” International Journal of Cancer, vol. 120, no. 12, pp. 2527–2537, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Y. Rapoport, A. M. Kennedy, J. E. Shea, C. L. Scaife, and K.-H. Nam, “Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles,” Journal of Controlled Release, vol. 138, no. 3, pp. 268–276, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. C.-Y. Lin, Y.-L. Huang, J.-R. Li, F.-H. Chang, and W.-L. Lin, “Effects of focused ultrasound and microbubbles on the vascular permeability of nanoparticles delivered into mouse tumors,” Ultrasound in Medicine and Biology, vol. 36, no. 9, pp. 1460–1469, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. A. S. Lübbe, C. Alexiou, and C. Bergemann, “Clinical applications of magnetic drug targeting,” Journal of Surgical Research, vol. 95, no. 2, pp. 200–206, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Alexiou, W. Arnold, R. J. Klein et al., “Locoregional cancer treatment with magnetic drug targeting,” Cancer Research, vol. 60, no. 23, pp. 6641–6648, 2000. View at Google Scholar · View at Scopus
  19. A. Schroeder, R. Honen, K. Turjeman, A. Gabizon, J. Kost, and Y. Barenholz, “Ultrasound triggered release of cisplatin from liposomes in murine tumors,” Journal of Controlled Release, vol. 137, no. 1, pp. 63–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Kruskal, S. Goldberg, and R. Kane, Eds., Novel In Vivo Use of Conventional Ultrasound to Guide and Enhance Molecular Delivery and Uptake into Solid Tumors, 2001.
  21. A. Shakeri-Zadeh, G. A. Mansoori, A. R. Hashemian, H. Eshghi, A. Sazgarnia, and A. R. Montazerabadi, “Cancerous cells targeting and destruction using folate conjugated gold nanoparticles,” Dynamic Biochemistry, Process Biotechnology and Molecular Biology, vol. 4, pp. 6–12, 2010. View at Google Scholar
  22. A. Hashemian, H. Eshghi, G. Mansoori, A. Shakeri-Zadeh, and A. Mehdizadeh, “Folate-conjugated gold nanoparticles (synthesis, characterization and design for cancer cells nanotechnology-based targeting),” International Journal of Nanoscience and Nanotechnology, vol. 5, no. 1, article 25, 2010. View at Google Scholar
  23. A. Shakeri-Zadeh, M. Ghasemifard, and G. Ali Mansoori, “Structural and optical characterization of folate-conjugated gold-nanoparticles,” Physica E: Low-Dimensional Systems and Nanostructures, vol. 42, no. 5, pp. 1272–1280, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Shakeri-Zadeh, H. Eshghi, G. A. Mansoori, and A. R. Hashemian, “Gold nanoparticles conjugated with folic acid using mercaptohexanol as the linker,” Journal Nanotechnology Progress International, vol. 1, pp. 13–23, 2009. View at Google Scholar
  25. K. S. Brandenburg, A. Shakeri-Zadeh, R. Hashemian, and G. A. Mansoori, “Folate-conjugated gold nanoparticles for cancer nanotechnology applications,” in Proceedings of Nanotechnology Conference, pp. 404–407, June 2011. View at Scopus