Therapeutic Effect of Ficus lacor Aerial Roots of Various Fractions on Adjuvant-Induced Arthritic Rats

Table 1

Inhibition of adjuvant induced poly arthritis in rats (administered daily from days 15–21) by various extracts from Ficus lacor.

Groups	Isolated extracts	Dose mg/kg	Mean arthritic score ± S.E.M. for days
			15	16	17	18	19	20	21	22
I	Normal	1 mL i.p.	13.4±1.3	13.8±1.4	14.1±1.3	14.8±1.4	14.9±1.5	15.0±1.3	15.2±1.4	15.2±1.5
II	FLPE	50 mg i.p.	13.0±1.4	10.4±1.4	10.0±1.1	9.2±1.0^∗	9.0±1.0^∗	8.6±0.9^∗	8.0±0.8^∗	7.4±0.8^#
III	FLPE	100 mg i.p.	13.3±1.3	9.2±1.1^∗	9.1±1.0^∗	9±1.1^∗	8.4±0.9	8±0.8^@	7.4±0.8^#	7.0±0.9^#
IV	FLEA	50 mg i.p.	13.0±1.4	10.4±1.4	10.0±1.1	9.6±1.0	9.6±1.0^∗	9.2±0.9^∗	9.2±0.8^∗	9.0±0.8^@
V	FLEA	100 mg i.p.	13.3±1.3	10±1.1	9.6±1.0	9.6±1.0	9.6±1.0^∗	9.0±0.9^∗	9.0±0.8^∗	8.8±0.8^@
VI	FLCF	50 mg i.p.	13.0±1.4	10.9±1.4	10.8±1.1	10.9±1.0	10.7±1.0	10.7±0.9	10.6±0.8^∗	10.6±0.8^∗
VII	FLCF	100 mg i.p.	13.3±1.3	10.8±1.1	10.8±1.0	10.8±1.1	10.6±0.9	10.6±0.8	10.4±0.8^∗	10.4±0.9^∗
VIII	FLET	50 mg i.p.	13.0±1.4	10.4±1.4	10.0±1.1	9.6±1.0	9.2±1.0^∗	8.6±0.9^∗	8.0±0.8^∗	7.4±0.8^@
IX	FLET	100 mg i.p.	13.3±1.3	10±1.1	9.6±1.0	9±1.1^∗	8.4±0.9^∗	8±0.8^@	7.0±0.8^@	6.8±0.2^#
X	Indomethacin	2.5 mg i.p.	13.2±1.2	9.8±1.0^∗	9.3±1.0^∗	9±1.2^∗	8.7±0.8^#	7.6±0.8^@	7.0±0.9^@	6.4±0.8^#

Group I: arthritic rats treated with saline; Group II: arthritic rats treated with FLPE 50 mg/kg; Group III: arthritic rats treated with FLPE 100 mg/kg; Group IV: arthritic rats treated with FLEA 50 mg/kg; Group V: arthritic rats treated with FLEA 100 mg/kg; Group VI: arthritic rats treated with FLCF 50 mg/kg, Group VII: arthritic rats treated with FLCF-100 mg/kg; Group VIII: Arthritic rats treated with FLET 50 mg/kg, Group IX: arthritic rats treated FLET 100 mg/kg; Group X: arthritic rats treated with indomethacin; ∗P < 0.05, @P < 0.01, #P < 0.001 as compared to arthritic control.