Therapeutic Effect of Ficus lacor Aerial Roots of Various Fractions on Adjuvant-Induced Arthritic Rats

Table 5

Effect of various extracts from Ficus lacor on interleukin-1 (IL-1) and tumor necrosis factor- α (TNF-α) in serum of adjuvant induced poly arthritis in rats.

Groups	Isolated extracts	Dose (mg/kg)	IL-1	TNF-𝛼
I	Normal	1 mL i.p.	0.395±0.084	0.108±0.037
II	FLPE	50	0.575±0.105^∗∗	0.178±0.046^∗∗
III	FLPE	100	0.510±0.145^∗∗∗	0.159±0.043^∗∗∗
IV	FLEA	50	0.695±0.125	0.193±0.024
V	FLEA	100	0.745±0.165^∗	0.193±0.035^∗
VI	FLCF	50	0.720±0.156	0.188±0.029
VII	FLCF	100	0.760±0.176^∗	0.188±0.044^∗
VIII	FLET	50	0.595±0.135^∗∗	0.170±0.047^∗∗
IX	FLET	100	0.495±0.127^∗∗∗	0.155±0.025^∗∗∗
X	Indomethacin	2.5	0.475±0.142^∗∗∗	0.135±0.050^∗∗∗

Group I: arthritic control (saline), Group II: arthritic rats treated with from FLPE fraction 50 mg, Group III: arthritic rats treated with FLPE fraction 100 mg, Group IV: arthritic rats treated FLEA fraction 50 mg, Group V: arthritic rats treated with FLEA fraction 100 mg, Group VI: arthritic rats treated with FLCF fraction 50 mg, Group VII: arthritic rats treated with FLCF fraction 100 mg, Group VIII: arthritic rats treated with FLET fraction 50 mg, Group IX: arthritic rats treated with FLET 100 mg from Ficus lacor, Group X: arthritic rats treated with indomethacin 2.5 mg/kg. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 as compared to arthritic control.