Review Article
Metabolic Regulation of a Bacterial Cell System with Emphasis on Escherichia coli Metabolism
Table 3
Regulators involved in regulating glutamate-dependent acid resistance.
| Protein | Descriptor | Function in acid resistance |
| RpoD | σ
70 | Transcription of gadA/BC | RpoS | σ
38 | Transcription of gadX | EvgAS | Two-component signal transduction | Activates ydeO and gadE transcription
| YdeO | AraC-like regulator | Activates gadE transcription | GadE | LuxR-related activator | Required for acid resistance, binds to Gad box, activates transcription of gadA/BC, autoactivates gadE, and represses ydeO | GadX | AraC-like regulator | Activates gadE, coactivates gadA/BC, and represses gadW | GadW | AraC-like regulator | Inhibits RpoS production, activates gadE, can coactivate gadA/BC at pH 8 | Crp | cAMP receptor protein | Inhibits RpoS production | TrmE | Era-like GTPase | Activates gadE mRNA production and stimulates translation of gadA and gadB mRNA | HNS | Histone-like protein | Negative regulator | TorR | Response regulator of TMAO reductase | Negative regulator of gadE |
|
|
[333].
|