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ISRN Biomarkers
Volume 2013 (2013), Article ID 651494, 7 pages
http://dx.doi.org/10.1155/2013/651494
Research Article

Correlation between Body Mass Index and Thyroid Function in Euthyroid Individuals in Greece

Anastasios Milionis1 and Charalampos Milionis2

1Department of Endocrinology, Local Health Unit of N. Kosmos, Social Insurance Institute (IKA-ETAM), Machis Analatou and Lagoumitzi, 11744 Athens, Greece
2Directorate of Public Health, Region of Central Greece, Ainianon 2, 35100 Lamia, Greece

Received 19 June 2013; Accepted 24 August 2013

Academic Editors: A. Alaiya and R. Smith

Copyright © 2013 Anastasios Milionis and Charalampos Milionis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. J. Hoogwerf and F. Q. Nutall, “Long-term weight regulation in treated hyperthyroid and hypothyroid subjects,” American Journal of Medicine, vol. 76, no. 6, pp. 963–970, 1984. View at Google Scholar · View at Scopus
  2. S. Andersen, K. M. Pedersen, N. H. Bruun, and P. Laurberg, “Narrow individual variations in serum T4 and T3 in normal subjects: a clue to the understanding of subclinical thyroid disease,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 1068–1072, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Wartofsky and R. A. Dickey, “The evidence for a narrower thyrotropin reference range is compelling,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 9, pp. 5483–5488, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Gharib, R. M. Tuttle, H. J. Baskin, L. H. Fish, P. A. Singer, and M. T. McDermott, “Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society,” Endocrine Practice, vol. 10, no. 6, pp. 497–501, 2004. View at Google Scholar · View at Scopus
  5. A. Nyrnes, R. Jorde, and J. Sundsfjord, “Serum TSH is positively associated with BMI,” International Journal of Obesity, vol. 30, no. 1, pp. 100–105, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C. S. Fox, M. J. Pencina, R. B. D'Agostino et al., “Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample,” Archives of Internal Medicine, vol. 168, no. 6, pp. 587–592, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Knudsen, P. Laurberg, L. B. Rasmussen et al., “Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 7, pp. 4019–4024, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Iacobellis, M. C. Ribaudo, A. Zappaterreno, C. V. Iannucci, and F. Leonetti, “Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women,” Clinical Endocrinology, vol. 62, no. 4, pp. 487–491, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. Michalaki, A. G. Vagenakis, A. S. Leonardou et al., “Thyroid function in humans with morbid obesity,” Thyroid, vol. 16, no. 1, pp. 73–78, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Bastemir, F. Akin, E. Alkis, and B. Kaptanoglu, “Obesity is associated with increased serum TSH level, independent of thyroid function,” Swiss Medical Weekly, vol. 137, no. 29-30, pp. 431–434, 2007. View at Google Scholar · View at Scopus
  11. A. Roos, S. J. L. Bakker, T. P. Links, R. O. B. Gans, and B. H. R. Wolffenbuttel, “Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 2, pp. 491–496, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. O. Gumieniak, T. S. Perlstein, P. N. Hopkins et al., “Thyroid function and blood pressure homeostasis in euthyroid subjects,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 7, pp. 3455–3461, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Boivin, A. Camirand, F. Carli, L. J. Hoffer, and J. E. Silva, “Uncoupling protein-2 and -3 messenger ribonucleic acids in adipose tissue and skeletal muscle of healthy males: variability, factors affecting expression, and relation to measures of metabolic rate,” Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 5, pp. 1975–1983, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Manji, K. Boelaert, M. C. Sheppard, R. L. Holder, S. C. Gough, and J. A. Franklyn, “Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects,” Clinical Endocrinology, vol. 64, no. 2, pp. 125–128, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Figueroa, H. Vélez, and M. Irizarry-Ramírez, “Association of thyroid-stimulating hormone levels and body mass index in overweight hispanics in Puerto Rico,” Ethnicity & Disease, vol. 18, pp. 151–154, 2008. View at Google Scholar
  16. H. S. Shon, E. D. Jung, S. H. Kim, and J. H. Lee, “Free T4 is negatively correlated with body mass index in euthyroid women,” Korean Journal of Internal Medicine, vol. 23, no. 2, pp. 53–57, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Sestoft, “Metabolic aspects of the calorigenic effect of thyroid hormone in mammals,” Clinical Endocrinology, vol. 13, no. 5, pp. 489–506, 1980. View at Google Scholar · View at Scopus
  18. M. Krotkiewski, “Thyroid hormones in the pathogenesis and treatment of obesity,” European Journal of Pharmacology, vol. 440, no. 2-3, pp. 85–98, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. J. L. Chan, K. Heist, A. M. DePaoli, J. D. Veldhuis, and C. S. Mantzoros, “The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men,” Journal of Clinical Investigation, vol. 111, no. 9, pp. 1409–1421, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. C. K. Welt, J. L. Chan, J. Bullen et al., “Recombinant human leptin in women with hypothalamic amenorrhea,” The New England Journal of Medicine, vol. 351, no. 10, pp. 987–997, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Zimmermann-Belsing, G. Brabant, J. J. Holst, and U. Feldt-Rasmussen, “Circulating leptin and thyroid dysfunction,” European Journal of Endocrinology, vol. 149, no. 4, pp. 257–271, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. S. H. Wang, A. Myc, R. J. Koenig, J. D. Bretz, P. L. Arscott, and J. R. Baker Jr., “2-methoxyestradiol, an endogenous estrogen metabolite, induces thyroid cell apoptosis,” Molecular and Cellular Endocrinology, vol. 165, no. 1-2, pp. 163–172, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Toni, A. Malaguti, S. Castorina, E. Roti, and R. M. Lechan, “New paradigms in neuroendocrinology: relationships between obesity, systemic inflammation and the neuroendocrine system,” Journal of Endocrinological Investigation, vol. 27, no. 2, pp. 182–186, 2004. View at Google Scholar · View at Scopus
  24. A. Sorisky, A. Bell, and A. Gagnon, “TSH receptor in adipose cells,” Hormone and Metabolic Research, vol. 32, no. 11-12, pp. 468–474, 2000. View at Google Scholar · View at Scopus
  25. A. Bell, A. Gagnon, L. Grunder, S. J. Parikh, T. J. Smith, and A. Sorisky, “Functional TSH receptor in human abdominal preadipocytes and orbital fibroblasts,” American Journal of Physiology: Cell Physiology, vol. 279, no. 2, pp. C335–C340, 2000. View at Google Scholar · View at Scopus
  26. A. Schäffler, N. Binart, J. Schölmerich, and C. Büchler, “Hypothesis paper: brain talks with fat—evidence for a hypothalamic-pituitary-adipose axis?” Neuropeptides, vol. 39, no. 4, pp. 363–367, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. R. W. Valyasevi, D. A. Harteneck, C. M. Dutton, and R. S. Bahn, “Stimulation of adipogenesis, peroxisome proliferator-activated receptor-γ (PPARγ), and thyrotropin receptor by PPARγ agonist in human orbital preadipocyte fibroblasts,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 5, pp. 2352–2358, 2002. View at Publisher · View at Google Scholar · View at Scopus