Amelioration of Sarcoptic Mange-Induced Oxidative Stress and Apoptosis in Dogs by Using Calendula officinalis Flower Extracts

Table 2

The markers of oxidative stress (lipid peroxides, reduced glutathione, glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, and catalase) in peripheral blood of dogs with sarcoptic mange and healthy control dogs at days 0 and 28 of therapy (mean ± SD).

Groups	Days	LPO; μmol MDA/mg Hb	Total thiol; ηmol/mg Hb	GSH-Px; mU/mg Hb	GST; mU/mg Hb	SOD; U/mg Hb	CAT; K/mg Hb
Group A; (Ivermectin + CFE )	0	1.945 ± 0.15^a	13.62 ± 1.6^a	6236.12 ± 192^a	0.602 ± 0.06^a	0.737 ± 0.10^a	89.25 ± 11^a
	28	0.843 ± 0.09^b	33.90 ± 3.9^b	8823.12 ± 206^b	0.931 ± 0.06^b	1.082 ± 0.06^b	153.25 ± 9^b
Group B; (Ivermectin + NAC )	0	1.875 ± 0.12^a	14.78 ± 2.5^a	6153.15 ± 159^a	0.618 ± 0.06^a	0.697 ± 0.12^a	89.62 ± 13^a
	28	0.808 ± 0.12^b	34.11 ± 2.5^b	8792.75 ± 309^b	0.908 ± 0.07^b	1.117 ± 0.05^b	144.50 ± 12^b
Group C; (Ivermectin)	0	1.947 ± 0.09^a	14.99 ± 2.0^a	6235.12 ± 197^a	0.592 ± 0.06^a	0.747 ± 0.11^a	95.25 ± 7.2^a
	28	1.270 ± 0.05	21.33 ± 1.7	7587.15 ± 364	0.712 ± 0.08	0.866 ± 0.07	117.75 ± 4.2
Group D; (Healthy)	0	0.720 ± 0.07	36.83 ± 2.5	8963.62 ± 113	0.987 ± 0.05	1.188 ± 0.03	176.25 ± 8.2

aStatistically significant differences (𝑃≤0.001) when compared with group D.
^bStatistically significant differences (𝑃≤0.001) when compared with the values pertaining at day 0.