Amelioration of Sarcoptic Mange-Induced Oxidative Stress and Apoptosis in Dogs by Using Calendula officinalis Flower Extracts

Table 3

Flow cytometric analysis of apoptotic leukocytes with externalization of phosphatidylserine (PS) and depolarized mitochondria (ΔΨm) in peripheral blood of dogs with sarcoptic mange and healthy control groups at days 0 and 28 of therapy (mean ± SD).

Groups	Days	Leukocytes with external PS (%)	Leukocytes with ΔΨm (%)
Group A; (Ivermectin + CFE)	0	21.87 ± 2.78^a	24.67 ± 2.34^a
	28	3.83 ± 1.50^b	7.69 ± 1.88^b
Group B; (Ivermectin + NAC)	0	21.38 ± 3.10^a	29.00 ± 1.46^a
	28	3.00 ± 1.01^b	7.09 ± 1.38^b
Group C; (Ivermectin)	0	22.92 ± 1.31^a	23.74 ± 2.17^a
	28	13.89 ± 1.67	17.40 ± 1.47
Group D; (Healthy)	0	2.13 ± 0.56	5.15 ± 1.04

aStatistically significant differences (𝑃≤0.001) when compared with group D.
^bStatistically significant differences (𝑃<0.001) when compared with the values pertaining at day 0.