SUMOhunt: Combining Spatial Staging between Lysine and SUMO with Random Forests to Predict SUMOylation
Figure 4
Frequency plot developed for all modified and unmodified instances with ten residues upstream and downstream of the target lysine; the plots are quite different from each other as expected. In the case of modified sites, there is a dominance of the conventional ΨKXE motif. Ψ is hydrophobic amino acid. Results show that aliphatic hydrophobic residues including valine, leucine, and isoleucine are dominant as compared to aromatic ones. K is the target lysine residue. X is any amino acid, which the results have shown it to be predominantly polar like glutamic acid, glutamine, and threonine. E is glutamic acid. In the dataset used here, about 76% sites follow the consensus motif.
