Table of Contents
ISRN Tropical Medicine
Volume 2013, Article ID 673798, 9 pages
http://dx.doi.org/10.1155/2013/673798
Clinical Study

How Reliable Are Hematological Parameters in Predicting Uncomplicated Plasmodium falciparum Malaria in an Endemic Region?

1Department of Medical Physiology, School of Biomedical Sciences, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda
2School of Medicine, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda

Received 23 April 2013; Accepted 16 May 2013

Academic Editors: M. Dell'Agli, P. Horrocks, and P. A. Nogueira

Copyright © 2013 Haruna Muwonge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization, Universal Access to Malaria Diagnostic Testing: an Operational Manual, WHO, Geneva, Switzerland, 2011.
  2. PMI, Rapid Assessment Report-Uganda, President's Malaria Initiative, 2005.
  3. F. T. M. Costa, M. Avril, P. A. Nogueira, and J. Gysin, “Cytoadhesion of Plasmodium falciparum-infected erythrocytes and the infected placenta: a two-way pathway,” Brazilian Journal of Medical and Biological Research, vol. 39, no. 12, pp. 1525–1536, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. I. M. B. Francischetti, “Does activation of the blood coagulation cascade have a role in malaria pathogenesis?” Trends in Parasitology, vol. 24, no. 6, pp. 258–263, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Ghosh and S. Shetty, “Blood coagulation in falciparum malaria—a review,” Parasitology Research, vol. 102, no. 4, pp. 571–576, 2008. View at Google Scholar
  6. I. A. Clark, A. C. Budd, L. M. Alleva, and W. B. Cowden, “Human malarial disease: a consequence of inflammatory cytokine release,” Malaria Journal, vol. 5, article 85, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Haldar and N. Mohandas, “Malaria, erythrocytic infection, and anemia,” Hematology/The Education Program of the American Society of Hematology, no. 10, pp. 87–93, 2009. View at Google Scholar · View at Scopus
  8. M. Jain, S. Gupta, J. Jain, and R. K. Grover, “Usefulness of automated cell counter in detection of malaria in a cancer set up-Our experience,” Indian Journal of Pathology and Microbiology, vol. 55, no. 4, pp. 467–473, 2012. View at Google Scholar
  9. I. O. George and C. S. Ewelike-Ezeani, “Haematological changes in children with malaria infection in Nigeria,” Journal of Medicine and Medical Sciences, vol. 2, no. 4, pp. 768–771, 2011. View at Google Scholar
  10. R. N. Maina, D. Walsh, C. Gaddy et al., “Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya,” Malaria Journal, vol. 9, no. 3, article S4, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Chandra and H. Chandra, “Role of haematological parameters as an indicator of acute malarial infection in uttarakhand state of India,” Mediterranean Journal of Hematology and Infectious Diseases, vol. 5, no. 1, Article ID e2013009, 2013. View at Publisher · View at Google Scholar
  12. G. G. Tchinda, J. Atashili, E. A. Achidi, H. L. Kamga, A. L. Njunda, and P. M. Ndumbe, “Impact of malaria on hematological parameters in people living with HIV/AIDS attending the Laquintinie Hospital in Douala, Cameroon,” PLoS ONE, vol. 7, no. 7, Article ID e40553, 2012. View at Publisher · View at Google Scholar
  13. World Health Organization, “New perspective: malaria diagnosis,” in Report of a Joint WHO/USAID Informal Consultation, WHO, Ed., pp. 4–5, WHO, Geneva, Switzerland, 1999. View at Google Scholar
  14. M. Ndao, “Diagnosis of parasitic diseases: old and new approaches,” Interdisciplinary Perspectives on Infectious Diseases, vol. 2009, Article ID 278246, 15 pages, 2009. View at Publisher · View at Google Scholar
  15. S. H. Abdalla, “Peripheral blood and bone marrow leucocytes in Gambian children with malaria: numerical changes and evaluation of phagocytosis,” Annals of Tropical Paediatrics, vol. 8, no. 4, pp. 250–258, 1988. View at Google Scholar · View at Scopus
  16. T. M. E. Davis, M. Ho, W. Supanaranond, S. Looareesuwan, S. Pukrittayakamee, and N. J. White, “Changes in the peripheral blood eosinophil count in falciparum malaria,” Acta Tropica, vol. 48, no. 3, pp. 243–246, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. B. González, H. Rodulfo, M. De Donato, M. Berrizbeitia, C. Gómez, and L. González, “Hematologic variations in patient with malaria caused by Plasmodium vivax before, during and after treatment,” Investigacion Clinica, vol. 50, no. 2, pp. 187–201, 2009. View at Google Scholar · View at Scopus
  18. H. Haroon, P. A. Fazel, M. Naeem, A. Mobin, A. H. Naqvi, and K. Makki, “Hide and seek: hematological aspects of malaria—a developing country perspective,” Journal of Infection in Developing Countries, vol. 7, no. 3, pp. 273–279, 2013. View at Google Scholar
  19. S. Akhtar, R. Gumashta, S. Mahore, and S. Maimoon, “Hematological changes in malaria: a comparative study,” Journal of Pharmacy and Biological Sciences, vol. 2, no. 4, pp. 15–19, 2012. View at Google Scholar
  20. E. Goldstein, “A clinical study of falciparum and vivax malaria in Vietnam servicemen,” Military Medicine, vol. 133, no. 12, pp. 991–996, 1968. View at Google Scholar · View at Scopus
  21. W. R. J. Taylor, H. Widjaja, H. Basri et al., “Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria,” Malaria Journal, vol. 7, article 259, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. S. H. Abdalla and G. Pasvol, Malaria: A Hematological Perspective, Imperial College Press, London, UK, 2004.
  23. M. W. Richards, R. H. Behrens, and J. F. Doherty, “Short report: Hematologic changes in acute, imported Plasmodium falciparum malaria,” American Journal of Tropical Medicine and Hygiene, vol. 59, no. 6, p. 859, 1998. View at Google Scholar · View at Scopus
  24. World Health Organization, World Malaria Report, Geneva, Switzerland, 2005.
  25. P. E. Okello, W. Van Bortel, A. M. Byaruhanga et al., “Variation in malaria transmission intensity in seven sites throughout Uganda,” American Journal of Tropical Medicine and Hygiene, vol. 75, no. 2, pp. 219–225, 2006. View at Google Scholar · View at Scopus
  26. A. Yeka, A. Gasasira, A. Mpimbaza et al., “Malaria in Uganda: challenges to control on the long road to elimination. I. Epidemiology and current control efforts,” Acta Tropica, vol. 121, no. 3, pp. 184–195, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. C. G. Reiley and O. Barrett Jr., “Leukocyte response in acute malaria,” American Journal of the Medical Sciences, vol. 262, no. 3, pp. 153–158, 1971. View at Google Scholar · View at Scopus
  28. I. S. Koltas, H. Demirhindi, S. Hazar, and K. Ozcan, “Supportive presumptive diagnosis of Plasmodium vivax malaria: thrombocytopenia and red cell distribution width,” Saudi Medical Journal, vol. 28, no. 4, pp. 535–539, 2007. View at Google Scholar · View at Scopus
  29. J. Chirenda and S. Murugasampillay, “Malaria and HIV co-infection: available evidence, gaps and possible interventions,” The Central African Journal of Medicine, vol. 49, no. 5-6, pp. 66–71, 2003. View at Google Scholar · View at Scopus
  30. L. Hviid, K. Kemp, P. Kern et al., “What is the cause of lymphopenia in malaria?” Infection and Immunity, vol. 68, no. 10, pp. 6087–6089, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. D. C. Dale and S. M. Wolff, “Studies of the neutropenia of acute malaria,” Blood, vol. 41, no. 2, pp. 197–206, 1973. View at Google Scholar · View at Scopus
  32. P. Kern, M. Dietrich, C. Hemmer, and N. Wellinghausen, “Increased levels of soluble Fas ligand in serum in Plasmodium falciparum malaria,” Infection and Immunity, vol. 68, no. 5, pp. 3061–3063, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. A. T. Baldé, J. Sarthou, and C. Roussilhon, “Acute Plasmodium falciparum infection is associated with increased percentages of apoptotic cells,” Immunology Letters, vol. 46, no. 1-2, pp. 59–62, 1995. View at Publisher · View at Google Scholar · View at Scopus
  34. S. M. el-Shoura, “Falciparum malaria in naturally infected human patients: IV—Ultrastructural changes in peripheral white blood cells,” Annales de Parasitologie Humaine et Comparee, vol. 68, no. 4, pp. 169–175, 1993. View at Google Scholar · View at Scopus
  35. Y. K. Kueh and K. L. Yeo, “Haematological alterations in acute malaria,” Scandinavian Journal of Haematology, vol. 29, no. 2, pp. 147–152, 1982. View at Google Scholar · View at Scopus
  36. S. J. Khan, Y. Abbass, and M. A. Marwat, “Thrombocytopenia as an indicator of malaria in adult population,” Malaria Research and Treatment, vol. 2012, Article ID 405981, 4 pages, 2012. View at Publisher · View at Google Scholar
  37. A. Kreil, C. Wenisch, G. Brittenham, S. Looareesuwan, and M. Peck-Radosavljevic, “Thrombopoietin in Plasmodium falciparum malaria,” British Journal of Haematology, vol. 109, no. 3, pp. 534–536, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. M. V. G. Lacerda, M. P. G. Mourão, H. C. Coelho, and J. B. Santos, “Thrombocytopenia in malaria: who cares?” Memorias do Instituto Oswaldo Cruz, vol. 106, no. 1, pp. 52–63, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. F. Moulin, F. Lesage, A-H. Legros et al., “Thrombocytopenia and Plasmodium falciparum malaria in children with different exposures,” Archives of Disease in Childhood, vol. 88, no. 6, pp. 540–541, 2003. View at Publisher · View at Google Scholar · View at Scopus