Cell Proliferation (KI-67) Expression Is Associated with Poorer Prognosis in Nigerian Compared to British Breast Cancer Women

Table 4

Relationship between biomarker expression in UK and Nigerian tumours expressing KI-67.

Variables		KI-67 positive expression
	Nigeria (%)	UK (%)	𝜒^2 value	P value
BRCA1
Negative	143 (80.8)	31 (21.5)	112.34	<0.001
Positive	34 (19.2)	113 (78.5)
Bcl-2
Negative	101 (57.4)	53 (37.6)	13.15	<0.001
Positive	75 (42.6)	88 (62.4)
CK5/6
Negative	108 (58.7)	137 (84.6)	27.90	<0.001
Positive	76 (41.3)	25 (15.4)
CK14
Negative	97 (58.8)	148 (90.8)	44.5	<0.001
Positive	68 (41.2)	15 (9.2)
ER
Negative	169 (84.5)	45 (28.0)	118.17	<0.001
Positive	31 (15.5)	116 (72.0)
EGFR
Negative	119 (66.5)	123 (80.4)	8.08	0.003
Positive	60 (33.5)	30 (19.6)
E-cadherin
Negative	119 (73.5)	65 (40.1)	36.7	<0.001
Positive	43 (26.5)	97 (59.9)
HER-2
Negative	148 (81.8)	140 (87.5)	2.13	0.14
Positive	33 (18.2)	20 (12.5)
PgR
Negative	126 (79.7)	68 (41.7)	48.53	<0.001
Positive	32 (20.3)	95 (58.3)
p27
Negative	131 (68.9)	45 (46.4)	13.77	<0.001
Positive	59 (31.1)	52 (53.6)
p21
Negative	152 (83.1)	65 (61.9)	16.07	<0.001
Positive	31 (16.9)	40 (38.1)
p53
Negative	1 (1.0)	10 (14.7)	13.11	<0.001
Positive	104 (99.0)	58 (85.3)
P-cadherin
Negative	81 (41.5)	66 (44.9)	0.38	0.54
Positive	114 (58.5)	81 (55.1)
Triple negative
No	68 (45.6)	128 (79.0)	37.10	<0.001
Yes	81 (54.4)	34 (21.0)
Classification
Basal	56 (49.1)	15 (10.2)	149.02	<0.001
HER-2	26 (22.8)	9 (6.2)
Luminal A	27 (23.7)	113 (77.4)
Luminal B	5 (4.4)	9 (6.2)