Table of Contents
ISRN Transplantation
Volume 2013 (2013), Article ID 680589, 6 pages
http://dx.doi.org/10.5402/2013/680589
Research Article

Low-Dose Valganciclovir for CMV Prophylaxis after Lung Transplantation

1Pulmonary and Critical Care, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
2Pulmonary and Critical Care, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
3Cardio-Thoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA

Received 21 October 2012; Accepted 6 November 2012

Academic Editors: W. Lim and H. Toz

Copyright © 2013 Hargobind S. Khurana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. A. Fishman and R. H. Rubin, “Infection in organ-transplant recipients,” The New England Journal of Medicine, vol. 338, no. 24, pp. 1741–1751, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Balthesen, M. Messerle, and M. J. Reddehase, “Lungs are a major organ site of cytomegalovirus latency and recurrence,” Journal of Virology, vol. 67, no. 9, pp. 5360–5366, 1993. View at Google Scholar · View at Scopus
  3. B. D. Alexander and V. F. Tapson, “Infectious complications of lung transplantation,” Transplant Infectious Disease, vol. 3, no. 3, pp. 128–137, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. D. R. Snydman, “Infection in solid organ transplantation,” Transplant Infectious Disease, vol. 1, no. 1, pp. 21–28, 1999. View at Google Scholar · View at Scopus
  5. N. Singh, P. M. Arnow, A. Bonham et al., “Invasive aspergillosis in liver transplant recipients in the 1990s,” Transplantation, vol. 64, no. 5, pp. 716–720, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Husain and N. Singh, “Bronchiolitis obliterans and lung transplantation: evidence for an infectious etiology,” Seminars in Respiratory Infections, vol. 17, no. 4, pp. 310–314, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Cerrina, F. Le Roy Ladurie, P. H. Herve et al., “Role of CMV pneumonia in the development of obliterative bronchiolitis in heart-lung and double-lung transplant recipients,” Transplant International, vol. 5, supplement 1, pp. S242–S245, 1992. View at Google Scholar · View at Scopus
  8. D. Weill, B. J. Lock, D. L. Wewers et al., “Combination prophylaxis with ganciclovir and cytomegalovirus (CMV) immune globulin after lung transplantation: effective CMV prevention following daclizumab induction,” American Journal of Transplantation, vol. 3, no. 4, pp. 492–496, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. M. R. Zamora, “Use of cytomegalovirus immune globulin and ganciclovir for the prevention of cytomegalovirus disease in lung transplantation,” Transplant Infectious Disease, vol. 3, no. 2, pp. 49–56, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Gane, F. Saliba, G. J. C. Valdecasas et al., “Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients,” The Lancet, vol. 350, no. 9093, pp. 1729–1733, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. S. R. Duncan, I. L. Paradis, J. H. Dauber, S. A. Yousem, R. L. Hardesty, and B. P. Griffith, “Ganciclovir prophylaxis for cytomegalovirus infections in pulmonary allograft recipients,” American Review of Respiratory Disease, vol. 146, no. 5, pp. 1213–1215, 1992. View at Google Scholar · View at Scopus
  12. M. D. Pescovitz, J. Rabkin, R. M. Merion et al., “Valganciclovir results in improved oral absorption of ganciclovir in liver transplant recipients,” Antimicrobial Agents and Chemotherapy, vol. 44, no. 10, pp. 2811–2815, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Paya, A. Humar, E. Dominguez et al., “Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients,” American Journal of Transplantation, vol. 4, no. 4, pp. 611–620, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Wiltshire, S. Hirankarn, C. Farrell, K. Zuideveld, and PV, 16000 Solid Organ Transplantation Study Group, “Cytomegalovirus suppression in relation to levels of ganciclovir exposure following valganciclovir prophylaxis in solid organ transplant recipients,” in Proceedings of the 43rd Interscience Conference on Antimicrob. Agents Chemother, vol. 40, American Society for Microbiology Press, Chicago, Ill, USA, 2003.
  15. M. D. Pescovitz, J. Rabkin, R. M. Merion et al., “Valganciclovir results in improved oral absorption of ganciclovir in liver transplant recipients,” Antimicrobial Agents and Chemotherapy, vol. 44, no. 10, pp. 2811–2815, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. L. S. Munoz, M. Angelis et al., “Valganciclovir for the treatment of CMV infections in transplant patients,” Infectious Disease Society of America, vol. 98, abstract 366, 2003.
  17. M. D. Pescovitz, “Oral ganciclovir and pharmacokinetics of valganciclovir in liver transplant recipients,” Transplant Infectious Disease, vol. 1, pp. 31–34, 1999. View at Google Scholar · View at Scopus
  18. T. H. Kiser, D. N. Fish, and M. R. Zamora, “Evaluation of valganciclovir pharmacokinetics in lung transplant recipients,” The Journal of Heart and Lung Transplantation, vol. 31, no. 2, pp. 159–166, 2011. View at Google Scholar
  19. I. Helanterä, L. Kyllönen, I. Lautenschlager, K. Salmela, and P. Koskinen, “Primary CMV infections are common in kidney transplant recipients after 6 months valganciclovir prophylaxis,” American Journal of Transplantation, vol. 10, no. 9, pp. 2026–2032, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Humar, D. Kumar, J. Preiksaitis et al., “A trial of valganciclovir prophylaxis for cytomegalovirus prevention in lung transplant recipients,” American Journal of Transplantation, vol. 5, no. 6, pp. 1462–1468, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. M. R. Zamora, M. R. Nicolls, T. N. Hodges et al., “Following universal prophylaxis with intravenous ganciclovir and cytomegalovirus immune globulin, valganciclovir is safe and effective for prevention of CMV infection following lung transplantation,” American Journal of Transplantation, vol. 4, no. 10, pp. 1635–1642, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. M. I. Hertz, C. Jordan, S. K. Savik et al., “Randomized trial of daily versus three-times-weekly prophylactic ganciclovir after lung and heart-lung transplantation,” Journal of Heart and Lung Transplantation, vol. 17, no. 9, pp. 913–920, 1998. View at Google Scholar · View at Scopus
  23. V. Monforte, C. Lopez, F. Santos et al., “A multicenter study of valganciclovir prophylaxis up to day 120 in CMV-Seropositive lung transplant recipients,” American Journal of Transplantation, vol. 9, no. 5, pp. 1134–1141, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Akalin, V. Sehgal, S. Ames et al., “Cytomegalovirus disease in high-risk transplant recipients despite ganciclovir or valganciclovir prophylaxis,” American Journal of Transplantation, vol. 3, no. 6, pp. 731–735, 2003. View at Publisher · View at Google Scholar · View at Scopus