Hemorrhagic Transformation (HT) and Symptomatic Intracerebral Hemorrhage (sICH) Risk Prediction Models for Postthrombolytic Hemorrhage in the Stroke Belt

Table 1

Risk scoring methodologies for hemorrhagic transformation or symptomatic intracerebral hemorrhage following thrombolytic therapy.

Investigator	Score title	Primary outcome measure	Points awarded	Conclusions
Cucchiara et al. [1]	None	HT	4-point score with 1 point allotted for; (i) age >60; (ii) baseline NIHSS >10; (iii) baseline serum glucose >8.325 mmol/L (150 mg/dL); (iv) baseline platelet count <150,000/mm^3	Proportion of patients with HT; (i) 0 points: 2.6%; (ii) 1 point: 9.7%; (iii) 2 points: 15.1%; (iv) 3 or 4 points: 37.9%; (AUC 0.69)
Mazya et al. [2]	SITS- sICH risk score	sICH	12-point score with 1 point allotted for; (i) baseline NIHSS 7–12; (ii) baseline systolic blood pressure ≥146 mmHg; (iii) age ≥72 years; (iv) body weight ≥95 kg; (v) stroke onset to treatment time ≥180 min; (vi) history of hypertension; 2 points allotted for; (i) baseline NIHSS >12; (ii) baseline serum glucose ≥180 mg/dL; (iii) current use of aspirin (3 points if current use of combined aspirin and clopidogrel)	Proportion of patients with sICH; (i) 0 points: 0.2%; (ii) ≥10 points: 14.3%; (AUC 0.70)
Saposnik et al. [3]	SPAN-100	HT	Composite score considered positive if; (i) age + baseline NIHSS ≥100	Proportion of patients with HT; (i) SPAN-100 positive group 42%; (ii) SPAN-100 negative group 12%; (𝑃<0.001)

Table is not comprehensive.
HT denotes hemorrhagic transformation; NIHSS: National Institutes of Health Stroke Scale; sICH: symptomatic intracerebral hemorrhage; CT: computed tomography of the head; MCA: middle cerebral artery; SITS: safe implementation of treatments in stroke; SPAN: stroke prognostication using age and National Institutes of Health Stroke Scale score.