Table of Contents
ISRN Genetics
Volume 2013, Article ID 694025, 7 pages
Research Article

No Association of Leptin Receptor Gene Gln223Arg Polymorphism with Capillary Glucose Levels: A Preliminary Population Base Cross-Sectional Study

1Departamento de Enfermagem Materno-Infantil e Saúde Pública, Escola de Enfermagem, Universidade Federal de Minas Gerais, 30130100 Belo Horizonte, MG, Brazil
2Departamento de Odontologia, Programa de Ciências da Saúde, Universidade Estadual de Montes Claros, 39401001 Montes Claros, MG, Brazil

Received 14 June 2013; Accepted 17 July 2013

Academic Editors: B.-H. Jeong, M. Stemmler, and D. Sun

Copyright © 2013 Geórgia das Graças Pena et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The leptin receptor gene has been reported to associate with insulin and glucose metabolism and adiposity in different study settings and various populations. Therefore, the aim of the study was to investigate the associations of the leptin receptor gene Gln223Arg polymorphism (LEPR Gln223Arg) with high capillary glucose levels. Cross-sectional study with probabilistic sample was carried out in individuals aged ≥18 years in an urban area of Montes Claros, MG, Brazil. The capillary glucose was considered high when ≥140 mg/dL. The genotypes of LEPR Gln223Arg distribution were as the following: 10.43% GG ( ), 46.81% AG ( ), and 42.77% AA ( ), and there were no prevalence differences between genders, ( ). Multivariate-adjusted models showed that there is no association between the polymorphism LEPR Gln223Arg and capillary high levels of glucose even when adjusted for age, sex, smoking, schooling, and parental history of obesity. In conclusion, no association between the polymorphism LEPR Gln223Arg and elevated blood glucose levels was detected.