The Role of Chronic Inflammation in Obesity-Associated Cancers

Figure 2

Important molecules during fat release by the WAT’s adipocyte. Lipid release from the adipocyte is in part triggered via (a) hormonal activation of hormone-sensitive lipase (HSL); (b) the adipose fatty acid binding protein (aFABP), a carrier protein for free fatty acids, eicosanoids, and retinoids, thought to facilitate the transfer of fatty acids between extra- and intracellular membranes, and lipophilic molecules from outer cell membrane to intracellular receptors such as PPAR; (c) aquaporin 7 which exports the glycerol molecule released from TAGs; and (d) CD36 which facilitates free fatty acid transport through the plasma membrane.