MHC Disparate Resting B Cells Are Tolerogenic in the Absence of Alloantigen-Expressing Dendritic Cells

Figure 5

CD2-D^d DC accelerate D^d skin graft rejection. CD11c⁺ cells from the indicated strains were isolated by MACS magnetic separation and administered i.v. to FVB recipients. Two weeks later, recipient mice were engrafted with MHC-D^d tail skin. Plots A-D represent log doses of DC administered: (a) 10³ DC, (b) 10⁴ DC, (c) 10⁵ DC, and (d) 10⁶ DC.

(a)

(b)

(c)

(d)