Table of Contents
ISRN Stem Cells
Volume 2013 (2013), Article ID 713959, 35 pages
http://dx.doi.org/10.1155/2013/713959
Review Article

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

Regenerative Bioengineering and Repair Laboratory and Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

Received 30 September 2012; Accepted 23 October 2012

Academic Editors: A. Chapel and S. M. Hwang

Copyright © 2013 Patricia Zuk. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In 2001, researchers at the University of California, Los Angeles, described the isolation of a new population of adult stem cells from liposuctioned adipose tissue. These stem cells, now known as adipose-derived stem cells or ADSCs, have gone on to become one of the most popular adult stem cells populations in the fields of stem cell research and regenerative medicine. As of today, thousands of research and clinical articles have been published using ASCs, describing their possible pluripotency in vitro, their uses in regenerative animal models, and their application to the clinic. This paper outlines the progress made in the ASC field since their initial description in 2001, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo, their use in mediating inflammation and vascularization during tissue regeneration, and their potential for reprogramming into induced pluripotent cells.