Characterization of the Visceral Antinociceptive Effect of Glial Glutamate Transporter GLT-1 Upregulation by Ceftriaxone
Figure 4
(a)-(b) Cyclophosphamide (1 wk VEH + 1 wk CYP) significantly increased the visceromotor to urinary bladder distension at 0.15 and 0.2 mL, compared to 1 wk VEH + 1 wk VEH controls. (*). (a) The enhanced visceromotor response produced in the 1 wk VEH + CYP group was attenuated by 1 wk daily CTX administration (1 wk CTX (200 mg/kg) + 1 wk CYP). (b) Administration of a lower dose of CTX (100 mg/kg; i.p.) for seven days also attenuated the enhanced visceromotor response to bladder distension of mice treated with cyclophosphamide (80 mg/kg) during the 7-day period prior to undergoing bladder distension (*).
