Use of Two Sulfonphthalein Dyes for the Sensitive and Selective Extraction-Free Spectrophotometric Assay of Albendazole in Bulk Drug and in Tablets

Table 6

Comparison of the performance characteristics of the present methods with the published method Spectrophotometry.

Serial number	Reagentes used	Methodology	𝜆max (nm)	Linear range (µg/mL^−1); 𝜀 (L mol^−1cm^−1)	Remarks	Reference
1	CAT-methyl orange/indigocarmine	Unreacted CAT measured using methyl orange/indigocarmine in acid medium	510; 610	—	Employs unstable oxidant	[6]
2	CAT-metol-Ar. aldehyde	Measurement of unreacted CAT with metol and Ar. aldehyde at pH 2.70 ± 0.1	520	2.5–25; 6.24 × 10^3	Employs unstable oxidant, multiple step reaction, strict pH control	[7]
3	KBrO3-KBr mixture-MO	Kinetic measurement of unreacted bromine using methyl orange	510	0.5–4.0; 2.89 × 10^4	Strict control of experimental variables; required	[8]
4	KBrO3-KBr mixture in acid medium	Measurement of residual bromine using methyl orange in acid medium	—	5–25	—	[9]
5	NBS-methyl orange/indigo carmine	Measurement of absorbance of acid form of methyl orange or indigocarmine	520	1.5–4.0; 3.45 × 10^4	Employs unstable oxidant
			610	8–16; 1.13 × 10^4		[10]
6	NCS-Fe (II)-SCN−	Measurement of absorbance of iron (III)-SCN−complex	480	0.62–10.0; 4.14 × 10^4	Employs unstable oxidant, multiple step; reaction and multi reagents	[11]
7	NaIO4	Measurement of acid form of methyl orange or indigo carmine	520	0.5–5.0; 2.92 × 10^4
			610	2.5–25; 5.11 × 10^3	—	[12]
8	NBS-iron-(II-) thiocyanate or tiron	Measurement of absorbance of iron-(III-) thiocyanate or tiron complex		0.5–5.0; 4.8 × 10^4	Employs unstable oxidant
			—	1–21; 1.1 × 10^4		[30]
9	Folin-Ciocalteu's reagent	Measurement of the absorbance of blue colored chromogen	700	—	—	[32]
10	∗p-CA	Measurement of absorbance of; charge transfer complex radical anion	525	0~280; 8.03 × 103	Less sensitive	[33]
11	(a) DDQ	Measurement of absorbance of; charge transfer complex radical anion	500	7.50–80; 1.83 × 10^3	Less sensitive
	(b) p-CAA		455	10–85; 1.12 × 10^3		[34]
12	∗BCG, BTB, BPB, and BPR in acidic medium	Measurement of absorbance of the ion-pair complex	420	2–12	Involves tedious; extraction step, rigid pH control, and use of large quantity of organic solvent	[35]
13	Thymol blue, alizarin (I), alizarin red S (II), alizarin yellow (III), quinalizarin (IV), alizarin fluorine blue (V), and thymol blue (VI)	Measurement of; ion-pair complex	—	6.6–92.8	Involves tedious; extraction step, rigid pH control, and use of large quantity of organic solvent, less sensitive	[36]
14	NBS-metol-sulfanilamide	CT complex involving metol-sulfanilamide measured	520		Employs unstable oxidant
	NBS-celesteine blue	Measurement of absorbance of CT complex	540	—		[37]
15	(a) Bromophenol blue	Measurement of absorbance of yellow coloured ion-pair complex in DCM	445	1.5–18.0; 1.27 × 10^4	Simple, highly sensitive, extraction free, and wide linear range
	(b) Bromothymol blue	Absorbance of yellow coloured ion-pair complex should be measured in DCM	460	2.0–32.0; 7.57 × 10^3	Simple, sensitive, extraction free, and wide linear range	Present; work

∗BCG: bromo cresol green, BTB: bromo thymol blue, BPB: bromo phenol blue, BPR: bromo phenol red, p-CAA: chloranilic acid.