Quality by Design Approach for the Development and Validation of Glipizide, an Antidiabetic Drug, by RP-UPLC with Application to Formulated Forms and Urine

Table 7

Results of determination of GPZ in formulations and statistical comparison with the reference method.

Formulation brand name^a	Nominal amount, mg	% GPZ found^c  ± SD		𝑡 value	𝐹 value
		Reference method	Proposed method
Dibizide^a	5.0	99.58 ± 0.78	98.88 ± 0.68	1.28	1.32
Glynase^b	5.0	100.2 ± 0.57	99.94 ± 0.97	0.53	2.9

^aMarketed by Micro Labs Limited, Hosur, India.
^bMarketed by USV Limited, Aurangabad, India.
^cMean value of five determinations. Tabulated 𝑡 value at 95% confidence level is 2.78; tabulated 𝐹 value at 95% confidence level is 6.39.