Table of Contents
ISRN Pharmaceutics
Volume 2013 (2013), Article ID 752471, 7 pages
http://dx.doi.org/10.1155/2013/752471
Research Article

Design and Development of Novel Dual-Compartment Capsule for Improved Gastroretention

Post-Graduate Department of Pharmaceutics, H R Patel Institute of Pharmaceutical Education and Research, Karvand Naka, Dhule District, Shirpur, Maharashtra 425 405, India

Received 30 October 2012; Accepted 11 December 2012

Academic Editors: A. N. Assimopoulou, A. Ghosal, S. Mutalik, and E. Pina

Copyright © 2013 Ganesh B. Patil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the proposed research work was to develop a novel dual-compartment capsule (NDCC) with polymeric disc for gastroretentive dosage form, which will ultimately result in better solubility and bioavailability of Ofloxacin. Floating ring caps were formulated by using different natural polymers, separating ring band and swellable polymer located at the bottom of capsule. Formulated ring caps were assessed for coating thickness, In vitro buoyancy, In vitro drug release, release kinetics and stability studies. Coating attained by the capsule shell was found to be 0.0643 mm. Depending on nature of natural polymer used, most of the formulations showed buoyancy for more than 9 hrs. Developed formulation demonstrated considerably higher drug release up to 9 hrs. The developed formulation depicted the drug release according to Korsmeyer-Peppas model. There was not any significant change in performance characteristics of developed ring caps after subjecting them to stability studies. The present study suggests that the use of NDCC for oral delivery of Ofloxacin could be an alternative to improve its systemic availability which could be regulated by the floating approach. The designed dosage system can have futuristic applications over payloads which require stomach-specific delivery.