Table of Contents
ISRN Cardiology
Volume 2013 (2013), Article ID 782508, 8 pages
Review Article

QRS Complex Enlargement as a Predictor of Ventricular Arrhythmias in Patients Affected by Surgically Treated Tetralogy of Fallot: A Comprehensive Literature Review and Historical Overview

Department of Medical Sciences “M. Aresu”, University of Cagliari, Policlinico Universitario, S.S. 554, bivio di Sestu, Monserrato, 09042 Cagliari, Italy

Received 30 December 2012; Accepted 16 January 2013

Academic Editors: G. Piccirillo, B. Strasberg, and A. Szekely

Copyright © 2013 Pier Paolo Bassareo and Giuseppe Mercuro. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tetralogy of Fallot (TOF) is a congenital heart disease frequently treated by surgical repair to relieve symptoms and improve survival. However, despite the performing of an optimal surgical repair, TOF patients are at times characterized by a poor long-term survival rate, likely due to cardiac causes such as ventricular arrhythmias, with subsequent sudden death. In the 80s it was irrefutably demonstrated that QRS prolongation ≥180 msec at basal electrocardiogram is a strong predictor for refining risk stratification for ventricular tachycardia in these patients. The aim of this research was to undertake a review of all studies conducted to assess the impact of QRS duration on the development of life-threatening ventricular arrhythmias in repaired TOF subjects.