Evaluation of Analgesic and Anti-Inflammatory Activity of Chloroform and Methanol Extracts of Centella asiatica Linn

Table 4

Protective effect of Centella asiatica extracts (methanol and chloroform) on tail withdrawal reflexes induced by tail immersion method in mice.

Drugs (dose)	Methanol			Chloroform
	Before treatment (sec)	After treatment (sec)	% Inhibition	After treatment (sec)	% Inhibition
Control (saline)	5.53±0.15	5.53±0.15	0.00	5.53±0.15	0.00
Dextropropoxyphene (65 mg/kg)	5.58±0.35	10.74±0.52^b	48.04	10.74±0.52^b	48.04
Extract (50 mg/kg)	5.57±0.19	6.64±0.19^a	19.21	6.19±0.16^a	10.01
Extract (100 mg/kg)	6.06±0.37	7.73±0.45^a	21.60	6.96±0.21^a	12.93
Extract (200 mg/kg)	6.07±0.33	8.45±0.54^a	28.16	7.91±0.37^a	23.26

Values are mean ± SEM (𝑛=6). Differences in groups were analyzed by one-way analysis of variances (one-way ANOVA) followed by Bonferroni posttest. ^a𝑃<0.05 and ^b𝑃<0.001 represented highly significant compared to control.