Evaluation of Analgesic and Anti-Inflammatory Activity of Chloroform and Methanol Extracts of Centella asiatica Linn

Table 6

Effect of methanol extract of Centella asiatica leaf on carrageenan-induced rat paw edema.

Treatment	Edema rate (mean ± SE) (𝑛=6)
	1 h	2 h	3 h	4 h
Control	34.63±1.18	94.90±3.05	122.26±2.24	125.65±2.21
Indomethacin (10 mg/kg)	13.31±0.80^b; (62.50%)	36.09±2.44^b; (61.97%)	42.84±2.60^b; (64.97%)	45.90±2.15^b; (63.46%)
Extract (100 mg/kg)	30.44±0.63; (12.09%)	69.86±1.62^b; (26.38%)	102.80±2.26^b; (16.35%)	111.74±0.90; (11.10%)
Extract (200 mg/kg)	26.26±0.51; (24.16%)	49.29±1.6^b; (48.06%)	71.29±0.93^b; (41.68%)	81.23±1.23^b; (35.35%)

Values are mean ± SEM (𝑛=6). The figure in parenthesis indicates the percentage inhibition. Differences in groups were analyzed by Student’s 𝑡-test compared with control ^b𝑃<0.001.